Rosai-Dorfman Disease of the Central Nervous System Report of 6 Cases and Review of the Literature

被引：113

作者：

Sandoval-Sus, Jose D. ^{[1
]}

Sandoval-Leon, Ana C. ^{[1
]}

Chapman, Jennifer R. ^{[2
]}

Velazquez-Vega, Jose ^{[2
]}

Borja, Maria J. ^{[3
]}

Rosenberg, Shai ^{[6
]}

Lossos, Alexander ^{[6
]}

Lossos, Izidore S. ^{[1
,4
,5
]}

机构：

[1] Univ Miami, Dept Med, Miami, FL 33136 USA

[2] Univ Miami, Dept Pathol, Miami, FL 33136 USA

[3] Univ Miami, Dept Radiol, Miami, FL 33136 USA

[4] Univ Miami, Sylvester Comprehens Canc Ctr, Dept Med, Div Hematol Oncol, Miami, FL 33136 USA

[5] Univ Miami, Sylvester Comprehens Canc Ctr, Dept Mol & Cellular Pharmacol, Miami, FL 33136 USA

[6] Hebrew Univ Jerusalem, Hadassah Med Ctr, Dept Neurol, Jerusalem, Israel

来源：

MEDICINE | 2014年 / 93卷 / 03期

基金：

美国国家卫生研究院;

关键词：

EXTRANODAL SINUS HISTIOCYTOSIS; SPINAL-CORD TUMOR; MASSIVE LYMPHADENOPATHY; INTRACRANIAL INVOLVEMENT; DURAL INVOLVEMENT; IMAGING FINDINGS; CERVICAL-SPINE; MIMICKING; LESIONS; MENINGIOMA;

D O I：

10.1097/MD.0000000000000030

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Rosai-Dorfman disease (RDD), also known as sinus histiocytosis with massive lymphadenopathy (SHML), is an uncommon benign idiopathic lymphoproliferative disorder. The histologic hallmark of RDD is the finding of emperipolesis displayed by lesional histiocytes. While RDD most commonly affects lymph nodes, extranodal involvement of multiple organs has been reported, including the central nervous system (CNS). However, CNS involvement in RDD is rare and is not well characterized. As a result, therapeutic approaches to CNS involvement in RDD are not well established. Herein we report 6 cases of RDD with isolated CNS involvement and review the literature on RDD with CNS involvement. One of the presented cases exhibited intramedullary involvement of the spinal cord-a very rare form of RDD with CNS involvement.

引用

页码：165 / 175

页数：11

共 128 条

[1] Diagnosis and management of Rosai-Dorfman disease involving the central nervous system [J].