Beam-shifting optical coherence tomography for speckle reduction and flow rate measurement

被引：0
作者：
Chen, Chaoliang [1 ]
Shi, Weisong [1 ,2 ]
Jivraj, Jamil [1 ]
Dobashi, Yuta [3 ,4 ]
Gao, Wanrong [2 ]
Yang, Victor X. D. [1 ,5 ,6 ]
机构：
[1] Ryerson Univ, Dept Elect Comp & Biomed Engn, Biophoton & Bioengn Lab, Toronto, ON, Canada
[2] Nanjing Univ Sci & Technol, Dept Opt Engn, Nanjing, Jiangsu, Peoples R China
[3] Univ British Columbia, Sch Biomed Engn, Vancouver, BC, Canada
[4] Univ Toronto, Inst Med Sci, Toronto, ON, Canada
[5] Sunnybrook Hlth Sci Ctr, Div Neurosurg, Toronto, ON, Canada
[6] Univ Toronto, Fac Med, Div Neurosurg, Toronto, ON, Canada
来源：
OPTICS IN HEALTH CARE AND BIOMEDICAL OPTICS IX | 2020年 / 11190卷
基金：
加拿大自然科学与工程研究理事会;
关键词：
Medical and biological imaging; optical coherence tomography; speckle reduction; flow rate measurement; IMAGES;
D O I：
10.1117/12.2538105
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
In this paper, beam-shifting optical coherence tomography (BSOCT) is presented for speckle reduction and flow rate measurement. The sample beam is rotated about the optical axis of the objective lens to modulate the incident angle on sample; 17 and 3 incident angles are respectively performed for speckle reduction and flow rate measurement. The performance of the proposed technique is investigated on both phantom and in vivo experiments. By combining a 2D micro-electro-mechanical system (MEMS) and a zigzag scanning protocol, the frame rates of 45.2 Hz for speckle reduction and 25.6 Hz for flow rate measurement are achieved. With beam-shifting angle of 4.76 degrees, the speckle noise reduction of 91% and the flow rate measurement precision of 0.0019 mu l/s are achieved.
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页数：8
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