Palladium-Catalyzed Ortho-Alkoxylation of N-Benzoyl α-Amino Acid Derivatives at Room Temperature

被引：27

作者：

Li, Shuangjie ^{[1
]}

Zhu, Wei ^{[2
]}

Gao, Feng ^{[2
]}

Li, Chunpu ^{[2
]}

Wang, Jiang ^{[2
]}

Liu, Hong ^{[2
]}

机构：

[1] China Pharmaceut Univ, Sch Pharm, Nanjing 210009, Jiangsu, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Mat Med, Key Lab Receptor Res, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2017年 / 82卷 / 01期

基金：

中国国家自然科学基金;

关键词：

C-H FUNCTIONALIZATION; UNACTIVATED C(SP(3))-H; C(SP(2))-H BONDS; ARENES; INHIBITORS; HYDROXYLATION; MECHANISM; TEMPLATE; ARYL;

D O I：

10.1021/acs.joc.6b02257

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient palladium-catalyzed ortho-alkoxylation of N-benzoyl alpha-amino acid derivatives at room temperature has been explored. This novel transformation, using amino acids as directing groups, Pd(OAc)(2) as catalyst, alcohols as the alkoxylation reagents, and PhI(OAc)(2) as the oxidant, showed wide generality, good functional tolerance, and high monoselectivity and regioselectivity.

引用

页码：126 / 134

页数：9

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