Sulfonamide-directed gold-catalyzed [2+2+2]-cycloadditions of nitriles with two discrete ynamides to construct 2,4-diaminopyridine cores

被引：55

作者：

Chen, Yu-Ling ^{[1
]}

Sharma, Pankaj ^{[1
]}

Liu, Rai-Shung ^{[1
]}

机构：

[1] Natl Tsing Hua Univ, Dept Chem, 101,Sec 2,Kuang Fu Rd, Hsinchu 30043, Taiwan

来源：

CHEMICAL COMMUNICATIONS | 2016年 / 52卷 / 15期

关键词：

2+2+2 CYCLOADDITIONS; ENANTIOSELECTIVE SYNTHESIS; RING-SYSTEMS; ALKYNES; DERIVATIVES; INHIBITORS; PYRIDINES; CYCLOTRIMERIZATION; DIYNES; ALPHA; OMEGA-DIYNES;

D O I：

10.1039/c5cc09688j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Gold-catalyzed [2+2+2]-cycloadditions of two discrete ynamides and one nitrile afford 2,4-diaminopyridine derivatives that are not readily prepared from typical low-valent-metal catalysts. Our mechanistic analysis reveals that the reaction chemoselectivity is controlled by the types of sulfonamides of ynamides.

引用

页码：3187 / 3190

页数：4

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