The effects of NMDA receptor antagonists on acute morphine antinociception in mice

被引：22
|
作者：
Kozela, E [1 ]
Popik, P [1 ]
机构：
[1] Polish Acad Sci, Inst Pharmacol, PL-31343 Krakow, Poland
来源：
AMINO ACIDS | 2002年 / 23卷 / 1-3期
关键词：
opiates; morphine; antinociception; pain; NMDA receptor antagonists; glutamate;
D O I：
10.1007/s00726-001-0123-5
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Antagonists of the N-methyl-D-aspartate (NMDA) receptor complex inhibit the development of tolerance to antinociceptive effects of morphine and upon acute administration, influence morphine antinociceptive activity. The analysis of numerous studies investigating acute interaction between NMDA receptor antagonists and morphine in mice indicate a variety of procedural differences and reveal that these compounds may potentiate, attenuate and produce no effect on morphine antinociception. The conditions responsible for such conflicting experimental outcome of acute interaction remain unclear. It appears that the effects of NMDA receptor antagonists on morphine tolerance are not causally related to their acute effects on morphine antinociception.
引用
收藏
页码：163 / 168
页数：6
相关论文
共 50 条
  • [41] ACEA-1328, a NMDA receptor/glycine site antagonist, acutely potentiates antinociception and chronically attenuates tolerance induced by morphine
    Lutfy, K
    Doan, P
    Weber, E
    PHARMACOLOGICAL RESEARCH, 1999, 40 (05) : 435 - 442
  • [42] GLUTAMATE, NMDA AND NMDA RECEPTOR ANTAGONISTS - CARDIOVASCULAR EFFECTS OF INTRATHECAL ADMINISTRATION IN THE RAT
    HONG, YG
    HENRY, JL
    BRAIN RESEARCH, 1992, 569 (01) : 38 - 45
  • [43] Morphine-induced catalepsy is augmented by NMDA receptor antagonists, but is partially attenuated by an AMPA receptor antagonist
    Tzschentke, TM
    Schmidt, WJ
    EUROPEAN JOURNAL OF PHARMACOLOGY, 1996, 295 (2-3) : 137 - 146
  • [44] Rodent antinociception following acute treatment with different histamine receptor agonists and antagonists
    Farzin, D
    Asghari, L
    Nowrouzi, M
    PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 2002, 72 (03) : 751 - 760
  • [45] EFFECTS OF FORSKOLIN AND PHOSPHODIESTERASE INHIBITORS ON SPINAL ANTINOCICEPTION BY MORPHINE
    NICHOLSON, D
    REID, A
    SAWYNOK, J
    PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1991, 38 (04) : 753 - 758
  • [46] Involvement of the nociceptin opioid peptide receptor in morphine-induced antinociception, tolerance and physical dependence in female mice
    Xiao-Qing Hao
    Zhi-Yuan Wang
    Jian-Min Chen
    Ning Wu
    Jin Li
    Metabolic Brain Disease, 2021, 36 : 2243 - 2253
  • [47] Involvement of the nociceptin opioid peptide receptor in morphine-induced antinociception, tolerance and physical dependence in female mice
    Hao, Xiao-Qing
    Wang, Zhi-Yuan
    Chen, Jian-Min
    Wu, Ning
    Li, Jin
    METABOLIC BRAIN DISEASE, 2021, 36 (08) : 2243 - 2253
  • [48] Enhanced antinociception by intrathecally-administered morphine in histamine H1 receptor gene knockout mice
    Mobarakeh, JI
    Sakurada, S
    Hayashi, T
    Orito, T
    Okuyama, K
    Sakurada, T
    Kuramasu, A
    Watanabe, T
    Watanabe, T
    Yanai, K
    NEUROPHARMACOLOGY, 2002, 42 (08) : 1079 - 1088
  • [49] Modulation of paracetamol antinociception by caffeine and by selective adenosine A2 receptor antagonists in mice
    Godfrey, L
    Yan, L
    Clarke, GD
    Ledent, C
    Kitchen, I
    Hourani, SMO
    EUROPEAN JOURNAL OF PHARMACOLOGY, 2006, 531 (1-3) : 80 - 86
  • [50] Endothelin receptor antagonists restore morphine analgesia in morphine tolerant rats
    Bhalla, S
    Matwyshyn, G
    Gulati, A
    PEPTIDES, 2003, 24 (04) : 553 - 561
12345