The effects of NMDA receptor antagonists on acute morphine antinociception in mice

被引：22
|
作者：
Kozela, E [1 ]
Popik, P [1 ]
机构：
[1] Polish Acad Sci, Inst Pharmacol, PL-31343 Krakow, Poland
来源：
AMINO ACIDS | 2002年 / 23卷 / 1-3期
关键词：
opiates; morphine; antinociception; pain; NMDA receptor antagonists; glutamate;
D O I：
10.1007/s00726-001-0123-5
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Antagonists of the N-methyl-D-aspartate (NMDA) receptor complex inhibit the development of tolerance to antinociceptive effects of morphine and upon acute administration, influence morphine antinociceptive activity. The analysis of numerous studies investigating acute interaction between NMDA receptor antagonists and morphine in mice indicate a variety of procedural differences and reveal that these compounds may potentiate, attenuate and produce no effect on morphine antinociception. The conditions responsible for such conflicting experimental outcome of acute interaction remain unclear. It appears that the effects of NMDA receptor antagonists on morphine tolerance are not causally related to their acute effects on morphine antinociception.
引用
收藏
页码：163 / 168
页数：6
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