Recent advances in the treatment of follicular lymphoma

被引:3
作者
Kobayashi, Yukio [1 ]
机构
[1] Natl Canc Ctr, Div Hematol, Chuo Ku, Tokyo 1040045, Japan
关键词
Follicular lymphoma; CD20; CD22; Radio-immmunotherapy; New agent study; ANTI-CD20; MONOCLONAL-ANTIBODY; IBRITUMOMAB TIUXETAN RADIOIMMUNOTHERAPY; PROTEASOME INHIBITOR BORTEZOMIB; PHASE-II; THERAPY; COMBINATION; RITUXIMAB; EPRATUZUMAB; CELLS;
D O I
10.1007/s10147-009-0904-5
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The success of anti-CD20 monoclonal antibody therapy for follicular lymphoma has encouraged efforts to identify new target molecules, and a new generation of more potent antibodies is now being developed, targeting either CD20 or other molecules. At the same time, other agents that were developed to treat other kinds of malignancies have turned out to be effective against this disease. In both treatment approaches, using either antibodies or chemical compounds, data on such trials are accumulating. In this mini-review these agents are introduced, and it is noted that clinical trials of these new agents are also ongoing in Japan.
引用
收藏
页码:191 / 196
页数:6
相关论文
共 35 条
[1]  
Advani R, 2006, BLOOD, V108, p209A
[2]   Anti-CD20 monoclonal antibody with enhanced affinity for CD16 activates NK cells at lower concentrations and more effectively than rituximab [J].
Bowles, Julie A. ;
Wang, Siao-Yi ;
Link, Brian K. ;
Allan, Barrett ;
Beuerlein, Gregory ;
Campbell, Mary-Ann ;
Marquis, David ;
Ondek, Brian ;
Wooldridge, James E. ;
Smith, Brian J. ;
Breitmeyer, James B. ;
Weiner, George J. .
BLOOD, 2006, 108 (08) :2648-2654
[3]   Pharmaco kinetics and pharmacodynamics from a first-in-human phase 1 dose escalation study with antagonist anti-CD40 antibody, HCD122 (formerly CHIR-12.12), in patients with relapsed and refractory chronic lymphocytic leukemia. [J].
Byrd, John C. ;
Flinn, Ian W. ;
Khan, Khuda D. ;
Kipps, Thomas J. ;
Aukerman, Lea ;
Fox, Judith ;
Girish, Sandhya ;
Guzy, Serge ;
Bilic, Sanela ;
Solinger, Alan ;
Dort, Sherri ;
Wang, Yongyu ;
Hurst, Deborah ;
O'Brien, Susan .
BLOOD, 2006, 108 (11) :803A-803A
[4]   Comparison of results from a phase 1/2 study of lumiliximab (Anti-CD23) in combination with FCR for patients with relapsed CLL with published FCR results. [J].
Byrd, John C. ;
Castro, Januario ;
O'Brien, Susan ;
Flinn, Ian W. ;
Forero-Torres, Andres ;
Kipps, Thomas J. ;
Heerema, Nyla A. ;
Lin, Thomas ;
Kheoh, Thian ;
Wynne, Dee ;
Molina, Arturo .
BLOOD, 2006, 108 (11) :14A-14A
[5]   Drug therapy: Monoclonal antibody therapy for B-cell non-Hodgkin's lymphoma [J].
Cheson, Bruce D. ;
Leonard, John P. .
NEW ENGLAND JOURNAL OF MEDICINE, 2008, 359 (06) :613-626
[6]   Bendamustine: Rebirth of an Old Drug [J].
Cheson, Bruce D. ;
Rummel, Mathias J. .
JOURNAL OF CLINICAL ONCOLOGY, 2009, 27 (09) :1492-1501
[7]   Genome-wide profiling of follicular lymphoma by array comparative genomic hybridization reveals prognostically significant DNA copy number imbalances [J].
Cheung, K. -John J. ;
Shah, Sohrab P. ;
Steidl, Christian ;
Johnson, Nathalie ;
Relander, Thomas ;
Telenius, Adele ;
Lai, Betty ;
Murphy, Kevin P. ;
Lam, Wan ;
Al-Tourah, Abdulwahab J. ;
Connors, Joseph M. ;
Ng, Raymond T. ;
Gascoyne, Randy D. ;
Horsman, Douglas E. .
BLOOD, 2009, 113 (01) :137-148
[8]   Radioimmunotherapy for non-Hodgkin's lymphoma [J].
Emmanouilides, C .
SEMINARS IN ONCOLOGY, 2003, 30 (04) :531-544
[9]   Phase II study of proteasome inhibitor bortezomib in relapsed or refractory B-Cell non-Hodgkin's lymphoma [J].
Goy, A ;
Younes, A ;
McLaughlin, P ;
Pro, B ;
Romaguera, JE ;
Hagemeister, F ;
Fayad, L ;
Dang, NH ;
Samaniego, F ;
Wang, M ;
Broglio, K ;
Samuels, B ;
Gilles, F ;
Sarris, AH ;
Hart, S ;
Trehu, E ;
Schenkein, D ;
Cabanillas, F ;
Rodriguez, AM .
JOURNAL OF CLINICAL ONCOLOGY, 2005, 23 (04) :667-675
[10]   First clinical use of ofatumumab, a novel fully human anti-CD20 monoclonal antibody in relapsed or refractory follicular lymphoma: results of a phase 1/2 trial [J].
Hagenbeek, Anton ;
Gadeberg, Ole ;
Johnson, Peter ;
Pedersen, Lars Moller ;
Walewski, Jan ;
Hellmann, Andrzej ;
Link, Brian K. ;
Robak, Tadeusz ;
Wojtukiewicz, Marek ;
Pfreundschuh, Michael ;
Kneba, Michael ;
Engert, Andreas ;
Sonneveld, Pieter ;
Flensburg, Mimi ;
Petersen, Jorgen ;
Losic, Nedjad ;
Radford, John .
BLOOD, 2008, 111 (12) :5486-5495