Toll-like receptors and IFN-α:: partners in autoimmunity

被引：25

作者：

Colonna, Marco ^{[1
]}

机构：

[1] Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63110 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2006年 / 116卷 / 09期

关键词：

D O I：

10.1172/JCI29879

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Many autoimmune diseases are thought to be precipitated by viral infections. In this issue of the JCI, Lang et al. demonstrate that, in a mouse model of autoimmune hepatitis, viral infections not only trigger expansion of self-reactive T cells but also activate antigen-presenting cells through TLR stimulation (see the related article beginning on page 2456). Activated cells then secrete IFN-alpha and TNF-alpha, which trigger tissue release of chemokines that attract self-reactive CD8(+) T cells, ultimately leading to liver damage.

引用

页码：2319 / 2322

页数：4

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