Cost-effectiveness of positron emission tomography-CT in the evaluation of cancer of unknown primary of the head and neck

被引：9

作者：

Smith, Kristine A. ^{[1
]}

Dort, Joseph C. ^{[1
]}

Hall, Stephen F. ^{[2
]}

Rudmik, Luke ^{[1
]}

机构：

[1] Univ Calgary, Div Otolaryngol Head & Neck Surg, Dept Surg, Calgary, AB T2N 2T9, Canada

[2] Queens Univ, Queens Canc Res Inst, Div Canc Care & Epidemiol, Dept Otolaryngol Head & Neck Surg, Kingston, ON K7L 3N6, Canada

来源：

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2015年 / 37卷 / 12期

关键词：

cost-effectiveness; positron emission tomography-CT; head and neck cancer; squamous cell carcinoma; unknown primary; SQUAMOUS-CELL CARCINOMA; LYMPH-NODE METASTASES; COMPUTED TOMOGRAPHY; PRIMARY TUMOR; CONVENIENT APPROXIMATION; DIAGNOSTIC EVALUATION; LIFE EXPECTANCY; PRIMARY SITE; WORK-UP; MANAGEMENT;

D O I：

10.1002/hed.23830

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Background. Positron emission tomography (PET)-CT is a useful diagnostic adjunct for cancer unknown primary (CUP) of the head and neck; however, the increased cost has not been justified with an economic evaluation in this patient population. Methods. A decision tree analysis was performed from the perspective of the third party payer. Primary outcome was cost per life year gained ($/LYG). The 2 comparative groups were: (1) PET-CT followed by panendoscopy versus (2) panendoscopy alone. Results. The incremental cost-effectiveness ratios for N1, N2, and N3 CUP were $369.83/LYG, $329.43/LYG, and $4900.28/LYG, respectively. The sensitivity analysis demonstrated a 96.8%, 97.1%, and 60.1% certainty that PET-CT is cost-effective for CUP with N1, N2, and N3 disease, respectively. Conclusion. The use of PET-CT in patients with N1 and N2 CUP is the cost-effective choice. The cost-effectiveness in N3 CUP is questionable and should be used on an individual case basis. (C) 2014 Wiley Periodicals, Inc.

引用

页码：1781 / 1787

页数：7

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