White matter changes with age utilizing quantitative diffusion MRI

被引：16

作者：

Baker, Laurie M. ^{[1
]}

Laidlaw, David H. ^{[2
]}

Conturo, Thomas E. ^{[5
]}

Hogan, Joseph ^{[3
,4
]}

Zhao, Yi ^{[3
,4
]}

Luo, Xi ^{[3
,4
]}

Correia, Stephen ^{[6
]}

Cabeen, Ryan ^{[2
]}

Lane, Elizabeth M. ^{[7
]}

Heaps, Jodi M. ^{[1
]}

Bolzenius, Jacob ^{[1
]}

Salminen, Lauren E. ^{[1
]}

Akbudak, Erbil ^{[5
]}

McMichael, Amanda R. ^{[5
]}

Usher, Christina ^{[1
]}

Behrman, Ashley ^{[1
]}

Paul, Robert H. ^{[1
]}

机构：

[1] Univ Missouri, St Louis, MO 63121 USA

[2] Brown Univ, Dept Comp Sci, Providence, RI 02912 USA

[3] Brown Univ, Dept Biostat, Providence, RI 02912 USA

[4] Brown Univ, Ctr Stat Sci, Providence, RI 02912 USA

[5] Washington Univ, Sch Med, Mallinckrodt Inst Radiol, St Louis, MO USA

[6] Brown Med Sch, Div Biol & Med, Providence, RI USA

[7] Vanderbilt Univ, Med Ctr, Nashville, TN 37235 USA

来源：

NEUROLOGY | 2014年 / 83卷 / 03期

关键词：

FIBER BUNDLE LENGTHS; HUMAN BRAIN; TRACTOGRAPHY METRICS; NERVE-FIBERS; TENSOR MRI; ANISOTROPY; IMAGES;

D O I：

10.1212/WNL.0000000000000597

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Objective: To investigate the relationship between older age and mean cerebral white matter fiber bundle lengths (FBLs) in specific white matter tracts in the brain using quantified diffusion MRI. Methods: Sixty-three healthy adults older than 50 years underwent diffusion tensor imaging. Tractography tracings of cerebral white matter fiber bundles were derived from the diffusion tensor imaging data. Results: Results revealed significantly shorter FBLs in the anterior thalamic radiation for every 1-year increase over the age of 50 years. Conclusions: We investigated the effects of age on FBL in specific white matter tracts in the brains of healthy older individuals utilizing quantified diffusion MRI. The results revealed a significant inverse relationship between age and FBL. Longitudinal studies of FBL across a lifespan are needed to examine the specific changes to the integrity of white matter.

引用

页码：247 / 252

页数：6

共 27 条

[1]

Basser PJ, 1996, J MAGN RESON SER B, V111, P209, DOI [10.1006/jmrb.1996.0086, 10.1016/j.jmr.2011.09.022]

[2] Cytokines and the aging brain - what we don't know might help us [J].