Icogenin, a new cytotoxic steroidal saponin isolated from Dracaena draco

被引：35

作者：

Hernández, JC

León, F

Quintana, J

Estévez, F

Bermejo, J

机构：

[1] Univ La Laguna, Inst Bioorgan Antonio Gonzalez, CSIC, Inst Prod Nat & Agrobiol, E-38206 Tenerife, Spain

[2] ICIC, E-38206 Tenerife, Spain

[3] Univ Las Palmas Gran Canaria, Dept Biochem Mol Biol & Physiol, Las Palmas Gran Canaria 35016, Spain

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2004年 / 12卷 / 16期

关键词：

D O I：

10.1016/j.bmc.2004.06.009

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This paper reports on the cytotoxic effect induced by a new natural steroidal saponin, icogenin, on the myeloid leukemia cell line HL-60. Icogenin was found to be a cytotoxic compound IC50 2.6 +/- 0.9 muM at 72 h, with growth inhibition caused by the induction of apoptosis, as deter-mined by microscopy of nuclear changes and the fragmentation of poly(ADP-ribose) polymerase-1. (C) 2004 Elsevier Ltd. All rights reserved.

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页码：4423 / 4429

页数：7

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