An intramolecular one-pot synthesis of steroidal triazoles via 1,3-dipolar cycloadditions of in situ generated diazo compounds

被引：23

作者：

Sakac, Marija N. ^{[1
]}

Gakovic, Andrea R. ^{[1
]}

Csanadi, Janos J. ^{[1
]}

Djurendic, Evgenija A. ^{[1
]}

Klisuric, Olivera ^{[2
]}

Kojic, Vesna ^{[3
]}

Bogdanovic, Gordana ^{[3
]}

Gasi, Katarina M. Penov ^{[1
]}

机构：

[1] Univ Novi Sad, Fac Sci, Dept Chem, Novi Sad 21000, Serbia

[2] Univ Novi Sad, Fac Sci, Dept Phys, Novi Sad 21000, Serbia

[3] Oncol Inst Vojvodina, Sremska Kamenica 21204, Serbia

来源：

TETRAHEDRON LETTERS | 2009年 / 50卷 / 28期

关键词：

Steroidal triazoles; 1,3-Dipolar cycloaddition; Nitriles; Dipolarophiles; In vitro cytotoxicity; DERIVATIVES;

D O I：

10.1016/j.tetlet.2009.04.107

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel synthetic route is reported for the preparation of steroidal triazoles via intramolecular 1,3-dipolar cycloaddition of a steroidal 16,17-seco-17-diazo-16-nitrile system. The structures of the products are established by X-ray and NMR studies. The in vitro antiproliferative activity of the steroidal triazoles against three tumor cell lines was evaluated. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：4107 / 4109

页数：3

共 13 条

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