FTY720: a novel transplantation drug that modulates lymphocyte traffic rather than activation

被引:146
作者
Brinkmann, V
Pinschewer, D
Chiba, K
Feng, LL
机构
[1] Nova Pharma AG, Transplantat Res, CH-4002 Basel, Switzerland
[2] Univ Zurich Hosp, Inst Expt Immunol, CH-8091 Munich, Germany
[3] Yoshitorni Pharmaceut, Iruma, Saitama 358, Japan
[4] Scripps Res Inst, La Jolla, CA 92037 USA
关键词
D O I
10.1016/S0165-6147(99)01419-4
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
引用
收藏
页码:49 / 52
页数:4
相关论文
共 30 条
[1]   DESIGN, SYNTHESIS, AND STRUCTURE-ACTIVITY-RELATIONSHIPS OF 2-SUBSTITUTED-2-AMINO-1,3-PROPANEDIOLS - DISCOVERY OF A NOVEL IMMUNOSUPPRESSANT, FTY720 [J].
ADACHI, K ;
KOHARA, T ;
NAKAO, N ;
ARITA, M ;
CHIBA, K ;
MISHINA, T ;
SASAKI, S ;
FUJITA, T .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1995, 5 (08) :853-856
[2]  
BRINKMANN V, TRANSPLANTATION, V67, pS226
[3]   Human safety and pharmacology of FTY 720 [J].
Brunkhorst, R ;
Neumayer, HH ;
Hiss, M ;
Budde, K ;
Lucker, P ;
Mayer, T ;
Brookman, L ;
Schmouder, R .
TRANSPLANTATION, 1999, 67 (07) :S153-S153
[4]   The identification of myriocin-binding proteins [J].
Chen, JK ;
Lane, WS ;
Schreiber, SL .
CHEMISTRY & BIOLOGY, 1999, 6 (04) :221-235
[5]  
Chiba K, 1996, TRANSPLANT P, V28, P1056
[6]  
Chiba K, 1998, J IMMUNOL, V160, P5037
[7]   Induction of tolerance toward rat cardiac allografts by treatment with allochimeric class I MHC antigen and FTY720 [J].
Chueh, SC ;
Tian, L ;
Wang, M ;
Wang, ME ;
Stepkowski, SM ;
Kahan, BD .
TRANSPLANTATION, 1997, 64 (10) :1407-1414
[8]   Potent immunosuppressants, 2-alkyl-2-aminopropane-1,3-diols [J].
Fujita, T ;
Hirose, R ;
Yoneta, M ;
Sasaki, S ;
Inoue, K ;
Kiuchi, M ;
Hirase, S ;
Chiba, K ;
Sakamoto, H ;
Arita, M .
JOURNAL OF MEDICINAL CHEMISTRY, 1996, 39 (22) :4451-4459
[9]   SIMPLE COMPOUNDS, 2-ALKYL-2-AMINO-1,3-PROPANEDIOLS HAVE POTENT IMMUNOSUPPRESSIVE ACTIVITY [J].
FUJITA, T ;
YONETA, M ;
HIROSE, R ;
SASAKI, S ;
INOUE, K ;
KIUCHI, M ;
HIRASE, S ;
ADACHI, K ;
ARITA, M ;
CHIBA, K .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1995, 5 (08) :847-852
[10]   2-SUBSTITUTED 2-AMINOETHANOL - MINIMUM ESSENTIAL STRUCTURE FOR IMMUNOSUPPRESSIVE ACTIVITY OF ISP-I (MYRIOCIN) [J].
FUJITA, T ;
HIROSE, R ;
HAMAMICHI, N ;
KITAO, Y ;
SASAKI, S ;
YONETA, M ;
CHIBA, K .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1995, 5 (16) :1857-1860