Role of myeloid-derived suppressor cells in immune checkpoint inhibitor therapy in cancer

被引：31

作者：

Park, Su-Myeong ^{[1
]}

Youn, Je-In ^{[2
,3
]}

机构：

[1] Yonsei Univ, Div Med Oncol, Yonsei Canc Ctr, Coll Med, Seoul, South Korea

[2] ProGen Inc, Res Inst, Seongnam 13488, Gyeonggido, South Korea

[3] Yonsei Univ, Dept Biochem, Coll Life Sci & Biotechnol, Seoul, South Korea

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2019年 / 42卷 / 07期

基金：

新加坡国家研究基金会;

关键词：

Myeloid-derived suppressor cells; Immune checkpoint inhibitor; Cancer; Immunotherapy; PD-L1; EXPRESSION; IMMUNOTHERAPY; BLOCKADE; MDSCS; LUNG;

D O I：

10.1007/s12272-019-01165-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Over the past decade, immune checkpoint inhibitor (ICI) therapy has demonstrated improved therapeutic efficacy in a wide range of cancers. However, the benefits are restricted to a small population of patients. Therefore, studies on understanding the mechanisms resistant to ICI therapy and for finding predictive biomarkers for ICI therapy are being actively conducted. Recent studies have demonstrated that myeloid-derived suppressor cells (MDSC) inhibit ICI therapy by various mechanisms, and that the response to ICI therapy can be improved by blocking MDSC activity. Moreover, low level of MDSC in patients with cancer has been shown to be correlated with their good prognosis after ICI treatment, thereby suggesting MDSC as a predictive biomarker in this regard. This review focuses on the roles of MDSC in ICI therapy and their relevant applications.

引用

页码：560 / 566

页数：7

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