Intrauterine Treatment of a Fetus with Familial Hypertrophic Cardiomyopathy Secondary to MYH7 Mutation

被引：4

作者：

Hill, Meghan G. ^{[1
]}

Sekhon, Mehtab K. ^{[1
]}

Reed, Kathryn L. ^{[1
]}

Anderson, Caroline F. ^{[1
]}

Borjon, Nydia D. ^{[1
]}

Tardiff, Jil C. ^{[1
]}

Barber, Brent J. ^{[1
]}

机构：

[1] Univ Arizona, Dept Obstet & Gynecol, Coll Med, Tucson, AZ 85724 USA

来源：

PEDIATRIC CARDIOLOGY | 2015年 / 36卷 / 08期

关键词：

Fetal hypertrophic cardiomyopathy; Beta myosin mutation; Propranolol; Fetal echocardiography;

D O I：

10.1007/s00246-015-1250-1

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

There is no clear consensus on optimal management of fetuses affected by familial hypertrophic cardiomyopathy (HCM). Intrauterine treatment of the condition has not been attempted in any standardized fashion. We report the case of a fetus treated by maternal propranolol during the third trimester after septal hypertrophy and diastolic dysfunction was diagnosed on fetal echocardiogram. The pregnancy went successfully to term, and fetal septal hypertrophy was noted to improve prior to delivery.

引用

页码：1774 / 1777

页数：4

共 11 条

[1] EFFECT OF PROPRANOLOL ON LEFT-VENTRICULAR RELAXATION IN HYPERTROPHIC CARDIOMYOPATHY - AN ECHOGRAPHIC STUDY [J].

BOURMAYAN, C ;

RAZAVI, A ;

FOURNIER, C ;

DUSSAULE, JC ;

BARAGAN, J ;

GERBAUX, A ;

GAY, J .

AMERICAN HEART JOURNAL, 1985, 109 (06) :1311-1316

[2]

Gersh BJ, 2011, CIRCULATION, V124, P2761, DOI 10.1161/CIR.0b013e318223e230

[3]

Goldberg BB., 2006, Atlas of ultrasound measurements, V2nd

[4] REFERENCE RANGES FOR FETAL VENOUS AND ATRIOVENTRICULAR BLOOD-FLOW PARAMETERS [J].

HECHER, K ;

CAMPBELL, S ;

SNIJDERS, R ;

NICOLAIDES, K .

ULTRASOUND IN OBSTETRICS & GYNECOLOGY, 1994, 4 (05) :381-390

[5] A Fetus with Hypertrophic Cardiomyopathy, Restrictive, and Single-Ventricle Physiology, and a β-Myosin Heavy Chain Mutation [J].

Hinton, Robert B. ;

Michelfelder, Erik C. ;

Marino, Bradley S. ;

Bove, Kevin E. ;

Ware, Stephanie M. .

JOURNAL OF PEDIATRICS, 2010, 157 (01) :164-166

[6] Genetics of Hypertrophic Cardiomyopathy After 20 Years Clinical Perspectives [J].

Maron, Barry J. ;

Maron, Martin S. ;

Semsarian, Christopher .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2012, 60 (08) :705-715

[7] PREVALENCE OF HYPERTROPHIC CARDIOMYOPATHY IN A GENERAL-POPULATION OF YOUNG-ADULTS - ECHOCARDIOGRAPHIC ANALYSIS OF 4111 SUBJECTS IN THE CARDIA STUDY [J].

MARON, BJ ;

GARDIN, JM ;

FLACK, JM ;

GIDDING, SS ;

KUROSAKI, TT ;

BILD, DE .

CIRCULATION, 1995, 92 (04) :785-789

[8] A cohort study of childhood hypertrophic cardiomyopathy -: Improved survival following high-dose beta-adrenoceptor antagonist treatment [J].

Östman-Smith, I ;

Wettrell, G ;

Riesenfeld, T .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1999, 34 (06) :1813-1822

[9] Fetal cardiomyopathies - Pathogenic mechanisms, hemodynamic findings, and clinical outcome [J].

Pedra, SRFF ;

Smallhorn, JF ;

Ryan, G ;

Chitayat, D ;

Taylor, GP ;

Khan, R ;

Abdolell, M ;

Hornberger, LK .

CIRCULATION, 2002, 106 (05) :585-591

[10]

VEILLE JC, 1992, OBSTET GYNECOL, V79, P51

← 1 2 →