Active droplet generation in microfluidics

被引:232
作者
Chong, Zhuang Zhi [1 ]
Tan, Say Hwa [2 ]
Ganan-Calvo, Alfonso M. [3 ]
Tor, Shu Beng [1 ]
Loh, Ngiap Hiang [1 ]
Nam-Trung Nguyen [2 ]
机构
[1] Nanyang Technol Univ, Sch Mech & Aerosp Engn, Singapore 639798, Singapore
[2] Griffith Univ, Queensland Micro & Nanotechnol Ctr, Brisbane, Qld 4111, Australia
[3] Univ Seville, Depto Ingn Aeroespacial & Mecan Fluidos, E-41092 Seville, Spain
关键词
FOCUSING DEVICE; MICRO-DROPLETS; VERSATILE TOOL; DYNAMICS; SIZE; MANIPULATION; EMULSIONS; BREAKUP; LIQUIDS; BUBBLES;
D O I
10.1039/c5lc01012h
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
The reliable generation of micron-sized droplets is an important process for various applications in droplet-based microfluidics. The generated droplets work as a self-contained reaction platform in droplet-based lab-on-a-chip systems. With the maturity of this platform technology, sophisticated and delicate control of the droplet generation process is needed to address increasingly complex applications. This review presents the state of the art of active droplet generation concepts, which are categorized according to the nature of the induced energy. At the liquid/liquid interface, an energy imbalance leads to instability and droplet breakup.
引用
收藏
页码:35 / 58
页数:24
相关论文
共 136 条
[1]   Valve-based flow focusing for drop formation [J].
Abate, Adam R. ;
Romanowsky, Mark B. ;
Agresti, Jeremy J. ;
Weitz, David A. .
APPLIED PHYSICS LETTERS, 2009, 94 (02)
[2]   Microscale tipstreaming in a microfluidic flow focusing device [J].
Anna, Shelley L. ;
Mayer, Hans C. .
PHYSICS OF FLUIDS, 2006, 18 (12)
[3]   Formation of dispersions using "flow focusing" in microchannels [J].
Anna, SL ;
Bontoux, N ;
Stone, HA .
APPLIED PHYSICS LETTERS, 2003, 82 (03) :364-366
[4]   Thermocapillary valve for droplet production and sorting [J].
Baroud, Charles N. ;
Delville, Jean-Pierre ;
Gallaire, Francois ;
Wunenburger, Regis .
PHYSICAL REVIEW E, 2007, 75 (04)
[5]   An optical toolbox for total control of droplet microfluidics [J].
Baroud, Charles N. ;
de Saint Vincent, Matthieu Robert ;
Delville, Jean-Pierre .
LAB ON A CHIP, 2007, 7 (08) :1029-1033
[6]   Dynamics of microfluidic droplets [J].
Baroud, Charles N. ;
Gallaire, Francois ;
Dangla, Remi .
LAB ON A CHIP, 2010, 10 (16) :2032-2045
[7]   Small-scale free surface flows with breakup: Drop formation and emerging applications [J].
Basaran, OA .
AICHE JOURNAL, 2002, 48 (09) :1842-1848
[8]   Physics and applications of microfluidics in biology [J].
Beebe, DJ ;
Mensing, GA ;
Walker, GM .
ANNUAL REVIEW OF BIOMEDICAL ENGINEERING, 2002, 4 :261-286
[9]   DROP FORMATION IN A CIRCULAR LIQUID JET [J].
BOGY, DB .
ANNUAL REVIEW OF FLUID MECHANICS, 1979, 11 :207-228
[10]   A microfluidic droplet generator based on a piezoelectric actuator [J].
Bransky, Avishay ;
Korin, Natanel ;
Khoury, Maria ;
Levenberg, Shulamit .
LAB ON A CHIP, 2009, 9 (04) :516-520