Lesions in the lungs of fatal corona virus disease Covid-19

被引：8

作者：

Englisch, Colya N. ^{[1
]}

Tschernig, Thomas ^{[1
]}

Flockerzi, Fidelis ^{[2
]}

Meier, Carola ^{[1
]}

Bohle, Rainer M. ^{[2
]}

机构：

[1] Saarland Univ, Inst Anat & Cell Biol, Campus Homburg,Kirrberger Str, D-66421 Homburg, Germany

[2] Saarland Univ, Inst Pathol, Homburg, Germany

来源：

ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER | 2021年 / 234卷

关键词：

SARS-CoV-2; Covid-19; Pathology; Lung lesions; Diffuse alveolar damage; Perivascular inflammation; Thrombi; Hyaline membranes; Angiogenesis; INTUSSUSCEPTIVE ANGIOGENESIS; PERIARTERIAL SPACE;

D O I：

10.1016/j.aanat.2020.151657

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

The corona virus outbreak in Wuhan, China, at the end of 2019 has rapidly evolved into a pandemic which is still virulent in many countries. An infection with SARS-CoV-2 can lead to corona virus disease (Covid-19). This paper presents an overview of the knowledge gained so far with regard to histopathological lung lesions in fatal courses of Covid-19. The main findings were diffuse alveolar damage and micro-angiopathies. These included the development of hyaline membranes, thrombi, endothelial inflammation, haemorrhages and angiogenesis. Overall, the vessel lesions seemed to be more lethal than the diffuse alveolar damage. There was obvious hyperreactivity and hyperinflammation of the cellular immune system. An expanded T-cell memory may explain the increased risk of a severe course in the elderly. (C) 2020 Elsevier GmbH. All rights reserved.

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页数：4

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