Point of view: Is cell size a spandrel?

被引：36
作者：
Amir, Ariel [1 ]
机构：
[1] Harvard Univ, Sch Engn & Appl Sci, Cambridge, MA 02138 USA
来源：
ELIFE | 2017年 / 6卷
关键词：
BACILLUS SUBTILIS CHROMOSOME; ESCHERICHIA-COLI-B/R; DIVISION CYCLE; DNA-REPLICATION; SEQUENTIAL REPLICATION; BUDDING-YEAST; GROWTH; BACTERIA; INITIATION; SHAPE;
D O I：
10.7554/eLife.22186
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
All organisms control the size of their cells. We focus here on the question of size regulation in bacteria, and suggest that the quantitative laws governing cell size and its dependence on growth rate may arise as byproducts of a regulatory mechanism which evolved to support multiple DNA replication forks. In particular, we show that the increase of bacterial cell size during Lenskis long-term evolution experiments is a natural outcome of this proposal. This suggests that, in the context of evolution, cell size may be a 'spandrel'
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页数：8
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