Peroxisome Proliferator-Activated Receptor γ in White and Brown Adipocyte Regulation and Differentiation

被引：31

作者：

Wu, Hui ^{[1
]}

Li, Xiaohua ^{[2
]}

Shen, Chunyan ^{[1
]}

机构：

[1] Shanghai Univ Tradit Chinese Med, Nutr Dept, Peoples Hosp 7, 358 Datong Rd, Shanghai 200137, Peoples R China

[2] Shanghai Univ Tradit Chinese Med, Endocrinol Dept, Peoples Hosp 7, Shanghai, Peoples R China

来源：

PHYSIOLOGICAL RESEARCH | 2020年 / 69卷 / 05期

关键词：

PPAR gamma; Adipocytes; White adipose tissue; Brown adipose tissue; Differentiation regulation; PPAR-GAMMA; ADIPOSE-TISSUE; BEIGE FAT; TRANSCRIPTIONAL REGULATION; STEM-CELLS; PRDM16; GROWTH; GENE; EXPRESSION; ALPHA;

D O I：

10.33549/physiolres.934411

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

In as early as 1997, the World Health Organization officially recognized obesity as a chronic disease. The current epidemic of obesity and overweightness has aroused great interest in the study of adipose tissue formation. The transcription factor peroxisome proliferator-activated receptor gamma (PPAR gamma) binds to the target gene promoter regulatory sequences, acting as a key factor in regulating the differentiation of preadipocytes in the adipose tissue, and plays an important role in regulating the adipocyte metabolism. A further understanding of the structure and expression characteristics of PPAR gamma, in addition to its mechanisms of action in adipocyte differentiation, may be applied to control obesity and prevent obesity-related diseases. In this article, recent studies investigating the effect of regulating PPAR gamma on adipocyte differentiation are reviewed. In particular, the structural characteristics, expression patterns, and molecular mechanisms of PPAR gamma function in adipocyte differentiation are considered.

引用

页码：759 / 773

页数：15

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