Animal models for COVID-19

被引：594

作者：

Munoz-Fontela, Cesar ^{[1
,2
]}

Dowling, William E. ^{[3
]}

Funnell, Simon G. P. ^{[4
]}

Gsell, Pierre-S. ^{[5
]}

Riveros-Balta, A. Ximena ^{[5
]}

Albrecht, Randy A. ^{[6
]}

Andersen, Hanne ^{[7
]}

Baric, Ralph S. ^{[8
]}

Carroll, Miles W. ^{[4
]}

Cavaleri, Marco ^{[9
]}

Qin, Chuan ^{[10
]}

Crozier, Ian ^{[11
]}

Dallmeier, Kai ^{[12
]}

de Waal, Leon ^{[13
]}

de Wit, Emmie ^{[14
]}

Delang, Leen ^{[12
]}

Dohm, Erik ^{[15
]}

Duprex, W. Paul ^{[16
]}

Falzarano, Darryl ^{[17
]}

Finch, Courtney L. ^{[18
]}

Frieman, Matthew B. ^{[19
]}

Graham, Barney S. ^{[20
]}

Gralinski, Lisa E. ^{[8
]}

Guilfoyle, Kate ^{[13
]}

Haagmans, Bart L. ^{[21
]}

Hamilton, Geraldine A. ^{[22
]}

Hartman, Amy L. ^{[16
]}

Herfst, Sander ^{[21
]}

Kaptein, Suzanne J. F. ^{[12
]}

Klimstra, William B. ^{[23
]}

Knezevic, Ivana ^{[5
]}

Krause, Philip R. ^{[24
]}

Kuhn, Jens H. ^{[18
]}

Le Grand, Roger ^{[25
]}

Lewis, Mark G. ^{[7
]}

Liu, Wen-Chun ^{[6
]}

Maisonnasse, Pauline ^{[25
]}

McElroy, Anita K. ^{[26
]}

Munster, Vincent ^{[14
]}

Oreshkova, Nadia ^{[27
]}

Rasmussen, Angela L. ^{[28
]}

Rocha-Pereira, Joana ^{[12
]}

Rockx, Barry ^{[21
]}

Rodriguez, Estefania ^{[1
,2
]}

Rogers, Thomas F. ^{[29
]}

Salguero, Francisco J. ^{[4
]}

Schotsaert, Michael ^{[6
]}

Stittelaar, Koert J. ^{[13
]}

Jan Thibaut, Hendrik ^{[12
]}

Tseng, Chien-Te ^{[30
]}

机构：

[1] Bernhard Nocht Inst Trop Med, Hamburg, Germany

[2] German Ctr Infect Res DZIF, Partner Site Hamburg Lubeck Borstel Riems, Hamburg, Germany

[3] Ctr Epidem Preparedness Innovat CEPI, Washington, DC USA

[4] Publ Hlth England, Natl Infect Serv, Salisbury, Wilts, England

[5] WHO, Geneva, Switzerland

[6] Icahn Sch Med Mt Sinai, Dept Microbiol, Global Hlth & Emerging Pathogens Inst, New York, NY 10029 USA

[7] Bioqual Inc, Rockville, MD USA

[8] Univ N Carolina, Dept Epidemiol, Chapel Hill, NC 27515 USA

[9] European Med Agcy, Amsterdam, Netherlands

[10] Chinese Acad Med Sci & Peking Union Med Coll, Inst Lab Anim Sci, Beijing, Peoples R China

[11] Frederick Natl Lab Canc Res, Clin Monitoring Res Program Directorate, Frederick, MD USA

[12] Katholieke Univ Leuven, Rega Inst, Lab Virol & Chemotherapy, Dept Microbiol Immunol & Transplantat, Leuven, Belgium

[13] Viroclin Xplore, Schaijk, Netherlands

[14] NIAID, Lab Virol, NIH, Hamilton, MT USA

[15] Univ Alabama Birmingham, Anim Resources Program, Birmingham, AL USA

[16] Univ Pittsburgh, Dept Microbiol & Mol Genet, Ctr Vaccine Res, Pittsburgh, PA USA

[17] Univ Saskatchewan, VIDO Intervac, Saskatoon, SK, Canada

[18] NIAID, Integrated Res Facil Ft Detrick, NIH, Frederick, MD USA

[19] Univ Maryland, Sch Med, Dept Microbiol & Immunol, Baltimore, MD 21201 USA

[20] NIAID, Vaccine Res Ctr, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA

[21] Erasmus MC, Dept Virosci, Rotterdam, Netherlands

[22] Emulate Inc, Boston, MA USA

[23] Univ Pittsburgh, Dept Immunol, Ctr Vaccine Res, Pittsburgh, PA USA

[24] US FDA, Ctr Biol Evaluat & Res, Silver Spring, MD USA

[25] Univ Paris Saclay, Ctr Immunol Viral Autoimmune Hematol & Bacterial, INSERM, CEA, Paris, France

[26] Univ Pittsburgh, Sch Med, Div Pediat Infect Dis, Ctr Vaccine Res, Pittsburgh, PA USA

[27] Wageningen Univ & Res, Wageningen Biovet Res WBVR, Lelystad, Netherlands

[28] Columbia Mailman Sch Publ Hlth, Ctr Infect & Immun, New York, NY USA

[29] Univ Calif San Diego, Div Infect Dis, San Diego, CA 92103 USA

[30] Univ Texas Med Branch, Dept Microbiol & Immunol, Galveston, TX 77555 USA

[31] Campus Univ Autonoma Barcelona, Ctr Recerca Sanitat Anim CReSA, IRTA UAB, Bellaterra, Spain

[32] Friedrich Loeffler Inst, Inst Diagnost Virol, Greifswald, Germany

[33] Univ Hong Kong, Li Ka Shing Fac Med, Dept Microbiol, Carol Yu Ctr Infect, Hong Kong, Peoples R China

[34] Univ Iowa, Dept Microbiol & Immunol, Iowa City, IA USA

[35] Kansas State Univ, Coll Vet Med, Manhattan, KS 66506 USA

[36] Tulane Natl Primate Res Ctr, Covington, LA USA

[37] UAB, Fac Vet, Dept Sanitat & Anat Anim, Bellaterra, Spain

[38] CSIRO, Australian Ctr Dis Preparedness, Geelong, Vic, Australia

[39] Univ York, Dept Hlth Sci, York, N Yorkshire, England

[40] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Ctr Virol & Vaccine Res, Boston, MA 02115 USA

来源：

NATURE | 2020年 / 586卷 / 7830期

关键词：

RESPIRATORY SYNDROME CORONAVIRUS; MOUSE MODEL; SARS; INFECTION; MICE; SARS-COV-2; MERS; PATHOGENESIS; RESERVOIRS; EFFICACY;

D O I：

10.1038/s41586-020-2787-6

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the aetiological agent of coronavirus disease 2019 (COVID-19), an emerging respiratory infection caused by the introduction of a novel coronavirus into humans late in 2019 (first detected in Hubei province, China). As of 18 September 2020, SARS-CoV-2 has spread to 215 countries, has infected more than 30 million people and has caused more than 950,000 deaths. As humans do not have pre-existing immunity to SARS-CoV-2, there is an urgent need to develop therapeutic agents and vaccines to mitigate the current pandemic and to prevent the re-emergence of COVID-19. In February 2020, the World Health Organization (WHO) assembled an international panel to develop animal models for COVID-19 to accelerate the testing of vaccines and therapeutic agents. Here we summarize the findings to date and provides relevant information for preclinical testing of vaccine candidates and therapeutic agents for COVID-19. The findings of a World Health Organization expert working group that is developing animal models to test vaccines and therapeutic agents for the treatment of COVID-19, and their relevance for preclinical testing, are reviewed.

引用

页码：509 / 515

页数：7

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