A Facile One-Pot Synthesis of Chloropyridines from Chalcones

被引：2

作者：

Menon, Prasanth K. ^{[1
,4
]}

Krishnaraj, K. U. ^{[1
]}

George, Sholly C. ^{[1
,3
]}

Devaky, K. S. ^{[1
]}

Anabha, E. R. ^{[1
,2
]}

机构：

[1] Mahatma Gandhi Univ, Sch Chem Sci, Kottayam 686560, Kerala, India

[2] Sree Narayana Coll, Dept Chem, Alathur 678622, Kerala, India

[3] NIIST, Div Organ Chem, Thiruvananthapuram, Kerala, India

[4] Synthite Ind Ltd, NPD, Cochin 682311, Kerala, India

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2014年 / 51卷 / 05期

关键词：

ALPHA-FORMYLAROYLKETENE DITHIOACETALS; VILSMEIER-HAACK REACTIONS; CONVENIENT PREPARATION; SUBSTITUTED PYRROLES; CARBONYL-COMPOUNDS; PYRIDINES; 2-AROYL-3,3-BIS(ALKYLSULFANYL)ACRYLALDEHYDES; NAPHTHYRIDINES; CYCLIZATION; REAGENTS;

D O I：

10.1002/jhet.1790

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Malononitrile undergoes Michael addition to iminoalkylated chalcones under Vilsmeier-Haack reaction condition. In situ intramolecular cyclization followed by aromatization of the adduct resulted in the formation of 4,6-bis(aryl)-2-chloropyridines in good yields.

引用

页码：1385 / 1389

页数：5

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