Developing zebrafish models relevant to PTSD and other trauma- and stressor-related disorders

被引：23

作者：

Stewart, Adam Michael ^{[1
,2
]}

Yang, Ester ^{[3
]}

Nguyen, Michael ^{[1
,2
,4
]}

Kalueff, Allan V. ^{[1
,2
]}

机构：

[1] ZENEREI Inst, Slidell, LA 70458 USA

[2] Int Zebrafish Neurosci Res Consortium ZNRC, Slidell, LA 70458 USA

[3] Mt Holyoke Coll, S Hadley, MA 01075 USA

[4] Univ Virginia, Dept Biomed Engn, Charlottesville, VA 22908 USA

来源：

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | 2014年 / 55卷

关键词：

Post-traumatic stress; Stressors; Translational research; Zebrafish; NATIONAL COMORBIDITY SURVEY; RECEPTOR ANTAGONIST MK-801; ACUTE RESTRAINT STRESS; DANIO-RERIO RESPONDS; WHOLE-BODY CORTISOL; POSTTRAUMATIC-STRESS; ANIMAL-MODELS; ADULT ZEBRAFISH; GENDER-DIFFERENCES; NEUROSCIENCE RESEARCH;

D O I：

10.1016/j.pnpbp.2014.08.003

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

While post-traumatic stress disorder (PTSD) and other trauma- and stress-related disorders (TSRDs) represent a serious societal and public health concern, their pathogenesis is largely unknown. Given the clinical complexity of TSRD development and susceptibility, greater investigation into candidate biomarkers and specific genetic pathways implicated in both risk and resilience to trauma becomes critical. In line with this, numerous animal models have been extensively used to better understand the pathogenic mechanisms of PTSD and related TSRD. Here, we discuss the rapidly increasing potential of zebrafish as models of these disorders, and how their use may aid researchers in uncovering novel treatments and therapies in this field. (C) 2014 Elsevier Inc. All rights reserved.

引用

页码：67 / 79

页数：13

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