Microwave Assisted Synthesis and Biological Activity of Novel Bis{2-[2-(substituted benzylidene)hydrazinyl]thiazole} Derivatives

New 4,4'-(4,6-dimethoxy-1,3-phenylene) bis{2-[2-(substituted benzylidene) hydrazinyl] thiazole} derivatives (5a-5j) have been synthesized from the corresponding 1,1'-(4,6-dimethoxy-1,3-phenylene) bis(2,2-dibromoethanone) and substituted thiosemicarbazones by the conventional method and under microwave irradiation. Structures of the synthesized compounds were characterized by FT-IR, H-1, and C-13 NMR and Mass spectra. The products were evaluated for their in vitro antibacterial activity against Gram-positive and Gram-negative stains. Some of the compounds 5b, 5f, 5h demonstrated high activity against B. subtilis (+ve), compound 5c exhibited high activity against E. coli (-ve) and P. aeruginosa (-ve) stains. Among the titled compounds also evaluated for their in vitro antimycobacterial activity, the product 5b demonstrated pronounced antimycobacterial activity against M. bovis stain.