Dynamic HPLC on chiral stationary phases: A powerful tool for the investigation of stereomutation processes

被引：98

作者：

D'Acquarica, Ilaria

Gasparrini, Francesco

Pierini, Marco

Villani, Claudio

Zappia, Giovanni

机构：

[1] Univ Roma La Sapienza, Dipartimento Studi Chim & Tecnol Sostanze Biologi, I-00185 Rome, Italy

[2] Univ Urbino, Inst Chem Sci, I-61029 Urbino, Italy

[3] Univ Urbino, Inst Pharmaceut Chem, I-61029 Urbino, Italy

来源：

JOURNAL OF SEPARATION SCIENCE | 2006年 / 29卷 / 10期

关键词：

dynamic HPLC; chiral stationary phases; stereomutation; enantiomerization; computer simulation;

D O I：

10.1002/jssc.200600129

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Dynamic HPLC on enantioselective stationary phases has become a well-established technique to investigate chiral molecules with internal motions that result in stereoinversion and occur on the time scale of the separation process. Kinetic parameters for the on-column interconversion phenomena can be extracted from experimental peak profiles by computer simulation or by direct calculation methods. The technique has been used in a wide range of temperatures and is complementary in scope to dynamic NMR spectroscopy.

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页码：1508 / 1516

页数：9

相关论文

共 39 条

[1]

AHUJA S, 1997, CHIRAL SEPARATIONS A

[2] Chromatography on chiral stationary phases [J].

Allenmark, S ;

Schurig, V .

JOURNAL OF MATERIALS CHEMISTRY, 1997, 7 (10) :1955-1963

[3] New biphenylic derivatives: synthesis, characterisation and enantiodiscrimination in chiral aggregates [J].

Andreani, R ;

Bombelli, C ;

Borocci, S ;

Lah, J ;

Mancini, G ;

Mencarelli, P ;

Vesnaver, G ;

Villani, C .

TETRAHEDRON-ASYMMETRY, 2004, 15 (06) :987-994

[4]

ARMSTRONG DW, 1998, LC GC EUR, V4, P22

[5] Internal motions in a fulleropyrrolidine tertiary amide with axial chirality [J].

Borsato, G ;

Della Negra, F ;

Gasparrini, F ;

Misiti, D ;

Lucchini, V ;

Possamai, G ;

Villani, C ;

Zambon, A .

JOURNAL OF ORGANIC CHEMISTRY, 2004, 69 (17) :5785-5788

[6] INFLUENCE OF TEMPERATURE ON CHIRAL HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC SEPARATIONS OF OXAZEPAM AND PROMINAL ON CHEMICALLY BONDED BETA-CYCLODEXTRIN AS STATIONARY-PHASE [J].

CABRERA, K ;

LUBDA, D .

JOURNAL OF CHROMATOGRAPHY A, 1994, 666 (1-2) :433-438

[7] Determination of enantiomerization barriers by computer simulation of experimental elution profiles obtained by high-performance liquid chromatography on a chiral stationary phase [J].

Cabrera, K ;

Jung, M ;

Fluck, M ;

Schurig, V .

JOURNAL OF CHROMATOGRAPHY A, 1996, 731 (1-2) :315-321

[8] ATROPISOMERISM IN HINDERED NAPHTHYL SULFONES INVESTIGATED BY DYNAMIC NMR AND DYNAMIC HPLC TECHNIQUES [J].

CASARINI, D ;

LUNAZZI, L ;

ALCARO, S ;

GASPARRINI, F ;

VILLANI, C .

JOURNAL OF ORGANIC CHEMISTRY, 1995, 60 (17) :5515-5519

[9] Determination of the rotational barrier of a chiral biphenyl: Comparison of theoretical and experimental data [J].

Ceccacci, F ;

Mancini, G ;

Mencarelli, P ;

Villani, C .

TETRAHEDRON-ASYMMETRY, 2003, 14 (20) :3117-3122

[10] Stereomutations of atropisomers of sterically hindered salophen ligands [J].

Dalla Cort, A ;

Gasparrini, F ;

Lunazzi, L ;

Mandolini, L ;

Mazzanti, A ;

Pasquini, C ;

Pierini, M ;

Rompietti, R ;

Schiaffino, L .

JOURNAL OF ORGANIC CHEMISTRY, 2005, 70 (22) :8877-8883

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