Three New 7.3′,8.5′-Connected Bicyclo[3.2.1]octanoids and Other Neolignans from Leaves of Nectandra amazonum NEES. (Lauraceae)

被引：21

作者：

Coy Barrera, Ericsson David ^{[1
]}

Cuca Suarez, Luis Enrique ^{[1
]}

机构：

[1] Univ Nacl Colombia, Fac Ciencias, Dept Quim, Lab Invest Prod Nat Vegetales, Bogota 14490, Colombia

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2009年 / 57卷 / 06期

关键词：

Nectandra amazonum; Lauraceae; macrophyllin-type bicyclo[3.2.1]octanoid; neolignan; BRAZILIAN LAURACEAE; CHEMISTRY; LIGNANS; ANTAGONISTS; PAF;

D O I：

10.1248/cpb.57.639

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Three new 7.3',8.5'-connected (macrophyllin-type) bicyclo[3.2.1]octanoid neolignans (nectamazins A-C, 1-3) were isolated from leaves of Nectandra amazonum NEES., along with seven known neolignans (4-10). The structures of 1-3 were characterized by spectroscopic methods (1D, 2D NMR) and the absolute configuration was assigned on the basis of circular dichroism (CD) spectra supported by nuclear Overhauser effect spectroscopy (NOESY) correlations. The new compounds showed inhibition activity against platelet activating factor (PAF)-induced aggregation of rabbit platelets.

引用

页码：639 / 642

页数：4

共 2 条

[1] 7.1′,8.3′- and 7.3′,8.5′-Connected Bicyclo[3.2.1]octanoids and Oxabicyclo[3.2.2]nonane-Type Neolignans from Ocotea aciphylla: Structures and Absolute Configurations
dos Santos, Carlos Henrique Totini
Petrica, Edith Eunice Arthur
de Luca Batista, Andrea Nastri
Rodrigues, Edilene Delphino
Garcez, Walmir Silva
de Albuquerque, Ana Carolina Ferreira
dos Santos Jr, Fernando Martins
Batista Jr, Joao Marcos
Garcez, Fernanda Rodrigues
JOURNAL OF NATURAL PRODUCTS, 2024, 87 (03): : 456 - 469
[2] PAF-antagonistic bicyclo[3.2.1]octanoid neolignans from leaves of Ocotea macrophylla Kunth. (Lauraceae)
Coy-Barrera, Ericsson D.
Cuca-Suarez, Luis E.
Sefkow, Michael
PHYTOCHEMISTRY, 2009, 70 (10) : 1309 - 1314

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