The Changing Geometry of a Fitness Landscape Along an Adaptive Walk

被引：35

作者：

Greene, Devin ^{[1
]}

Crona, Kristina ^{[1
]}

机构：

[1] Univ Calif Merced, Merced, CA 95343 USA

来源：

PLOS COMPUTATIONAL BIOLOGY | 2014年 / 10卷 / 05期

关键词：

BENEFICIAL MUTATIONS; SIGN EPISTASIS; EVOLUTION; MODEL;

D O I：

10.1371/journal.pcbi.1003520

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

It has recently been noted that the relative prevalence of the various kinds of epistasis varies along an adaptive walk. This has been explained as a result of mean regression in NK model fitness landscapes. Here we show that this phenomenon occurs quite generally in fitness landscapes. We propose a simple and general explanation for this phenomenon, confirming the role of mean regression. We provide support for this explanation with simulations, and discuss the empirical relevance of our findings.

引用

页数：10

共 30 条

[1] Fitness spectrum among random mutants on Mt Fuji-type fitness landscape [J].