Pheochromocytomas and Paragangliomas: From Genetic Diversity to Targeted Therapies

被引:36
作者
Pang, Ying [1 ]
Liu, Yang [2 ]
Pacak, Karel [1 ]
Yang, Chunzhang [2 ]
机构
[1] NIH, Sect Med Neuroendocrinol, Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Bethesda, MD 20892 USA
[2] Natl Canc Inst, Neurooncol Branch, Ctr Canc Res, Bethesda, MD 20892 USA
基金
美国国家卫生研究院;
关键词
pheochromocytoma; paraganglioma; neuroendocrine tumor; targeted therapy; therapy resistance; HIPPEL-LINDAU DISEASE; SUCCINATE-DEHYDROGENASE; MALIGNANT PHEOCHROMOCYTOMAS; SPORADIC PHEOCHROMOCYTOMA; INHIBITOR SUNITINIB; NECK PARAGANGLIOMAS; SOMATIC MUTATIONS; ENDOCRINE TUMORS; FACTOR; 1-ALPHA; SDH MUTATIONS;
D O I
10.3390/cancers11040436
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Pheochromocytoma and paraganglioma (PCPGs) are rare neuroendocrine tumors that arise from the chromaffin tissue of adrenal medulla and sympathetic ganglia. Although metastatic PCPGs account for only 10% of clinical cases, morbidity and mortality are high because of the uncontrollable mass effect and catecholamine level generated by these tumors. Despite our expanding knowledge of PCPG genetics, the clinical options to effectively suppress PCPG progression remain limited. Several recent translational studies revealed that PCPGs with different molecular subtypes exhibit distinctive oncogenic pathways and spectrum of therapy resistance. This suggests that therapeutics can be adjusted based on the signature molecular and metabolic pathways of PCPGs. In this review, we summarized the latest findings on PCPG genetics, novel therapeutic targets, and perspectives for future personalized medicine.
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页数:16
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