Prolonged shedding of pandemic influenza A (H1N1) 2009 virus in a pancreas-after-kidney transplant recipient

被引：7

作者：

Bruminhent, Jackrapong ^{[1
]}

Deziel, Paul J. ^{[2
]}

Wotton, Jason T. ^{[3
]}

Binnicker, Matthew J. ^{[4
]}

Razonable, Raymund R. ^{[1
,2
]}

机构：

[1] Mayo Clin, Div Infect Dis, Rochester, MN 55905 USA

[2] Mayo Clin, William J Von Liebig Ctr Transplantat & Clin Rege, Rochester, MN 55905 USA

[3] Minnesota Dept Hlth, St Paul, MN 55164 USA

[4] Mayo Clin, Dept Lab Med & Pathol, Div Clin Microbiol, Rochester, MN 55905 USA

来源：

JOURNAL OF CLINICAL VIROLOGY | 2014年 / 61卷 / 02期

关键词：

Influenza; Shedding; Immunocompromised; Transplant; Oseltamivir; Transmission; RESISTANT; OSELTAMIVIR; INFECTION; SELECTION;

D O I：

10.1016/j.jcv.2014.07.004

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Prolonged shedding of influenza virus has been reported in immunocompromised patients. Delayed viral clearance may contribute to antiviral resistance and nosocomial transmission. We report a case of a pancreas-after-kidney transplant recipient who had detectable pandemic influenza A virus for 12 months. Pyrosequencing analysis detected the H275Y mutation, which is associated with resistance to oseltamivir. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：302 / 304

页数：3

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