Synthesis of novel derivatives of 4-methylbenzimidazole and evaluation of their biological activities

被引：69

作者：

Taha, Muhammad ^{[1
,2
]}

Ismail, Nor Hadiani ^{[1
,2
]}

Jamil, Waqas ^{[3
]}

Rashwan, Hesham ^{[4
]}

Kashif, Syed Muhammad ^{[3
]}

Sain, Amyra Amat ^{[5
]}

Adenan, Mohd Ilham ^{[1
,5
,6
]}

Anouar, El Hassane ^{[1
]}

Ali, Muhammad ^{[7
]}

Rahim, Fazal ^{[9
]}

Khan, Khalid M. ^{[8
]}

机构：

[1] Univ Teknol MARA UiTM, Atta Ur Rahman Inst Nat Prod Discovery, Puncak Alam 42300, Selangor, Malaysia

[2] Univ Teknol MARA, Fac Sci Appl, Shah Alam 40450, Selangor, Malaysia

[3] Univ Sindh Jamshoro, Inst Adv Res Studies Chem Sci, Jamshoro, Pakistan

[4] Univ Teknol MARA, Fac Pharm, Puncak Alam 42300, Selangor, Malaysia

[5] Malaysian Inst Pharmaceut & Nutraceut, Minist Sci Technol & Innovat Bangunan Pentadbiran, Bayan Lepas 11700, Penang, Malaysia

[6] Forest Res Inst Malaysia, Kepong 52109, Selangor, Malaysia

[7] COMSATS Inst Informat Technol, Ctr Adv Drug Res, Abbottabad 22060, KPK, Pakistan

[8] Univ Karachi, Int Ctr Chem & Biol Sci, HEJ Res Inst Chem, Karachi 75270, Pakistan

[9] Hamra Univ, Dept Chem, Mansehra, Pakistan

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2014年 / 84卷

关键词：

Benzimidazole; Antiglycation; Antioxidant; Antileishmanial; Stereoisomers; SCHIFF-BASES; GLYCATION; HYDRAZONE; PRODUCTS;

D O I：

10.1016/j.ejmech.2014.07.078

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

4-Methylbenzimidazole 1-28 novel derivatives were synthesized and evaluated for their antiglycation and antioxidant activities. Compounds 1-7 and 11 showed excellent activities ranged 140-280 mu M, better than standard drug rutin (294.46 +/- 1.50 mu M). Compound 1-28 were also evaluated for DPPH activities. Compounds 1-8 showed excellent activities, ranging 12-29 mu M, better than standard drug n-propylgallate (IC50 = 30.30 +/- 0.40 mu M). For superoxide anion scavenging activity, compounds 1-7 showed better activity than standard n-propylgallate (IC50 = 106.34 +/- 1.6 mu M), ranged 82-104 mu M. These compounds were found to be nontoxic to THP-1 cells. (C) 2014 Elsevier Masson SAS. All rights reserved.

引用

页码：731 / 738

页数：8

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