Cryptococcus neoformans Fatal Sepsis in a Chronic Lymphocytic Leukemia Patient Treated with Alemtuzumab: Case Report and Review of the Literature

被引：13

作者：

Bassetti, M. ^{[1
]}

Repetto, E. ^{[1
]}

Mikulska, M. ^{[1
]}

Miglino, M. ^{[2
]}

Clavio, M. ^{[2
]}

Gobbi, M. ^{[2
]}

Righi, E. ^{[1
]}

Viscoli, C. ^{[1
]}

机构：

[1] San Martino Hosp, Div Infect Dis, Genoa, Italy

[2] San Martino Hosp, Dept Hematol, Genoa, Italy

来源：

JOURNAL OF CHEMOTHERAPY | 2009年 / 21卷 / 02期

关键词：

Chronic lymphocytic leukemia; alemtuzumab; cryptococcosis; liposomal amphothericin B; RECIPIENTS RECEIVING ALEMTUZUMAB; INFECTIOUS COMPLICATIONS; LYMPHOPROLIFERATIVE DISORDERS; RENAL-TRANSPLANTATION; PROGNOSTIC FACTORS; FUNGAL-INFECTIONS; INDUCTION; MALIGNANCIES; PROPHYLAXIS; MENINGITIS;

D O I：

10.1179/joc.2009.21.2.211

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cryptococcosis is a disseminated fungal disease typically associated with immunosuppression and characterized by high mortality rates. Cryptococcus neoformans has been reported to be isolated from blood cultures in around 20% of patients with cryptococcosis, and cryptococcemia has been correlated with poor prognosis. We report a case of fatal C. neoformans fungemia in a neutropenic patient with a history of chronic lymphocytic leukemia treated with alemtuzumab. The patient presented with loss of consciousness and died after 5 days of antifungal therapy with liposomal amphotericin B. The international literature regarding opportunistic infections after immunosuppressive therapy with alemtuzumab with particular attention on fungal infections has also been reviewed.

引用

页码：211 / 214

页数：4

共 21 条

[1] Cryptococcosis [J].