A review on the electrochemical biosensors for determination of microRNAs

被引：105
作者：
Hamidi-Asl, Ezat [1 ,2 ]
Palchetti, Ilaria [2 ]
Hasheminejad, Ehteram [1 ]
Mascini, Marco [2 ]
机构：
[1] Univ Mazandaran, Dept Analyt Chem, Eletroanalyt Chem Res Lab, Fac Chem, Babol Sar, Iran
[2] Univ Florence, Dipartimento Chim, I-50019 Sesto Fiorentino, Italy
来源：
TALANTA | 2013年 / 115卷
关键词：
MicroRNAs; Electrochemistry; Biosensors; MUSCLE-SPECIFIC MICRORNA; SMALL RNAS; DNA; EXPRESSION; NORTHERN; QUANTIFICATION; HYBRIDIZATION; MICROARRAY; REAL; OLIGONUCLEOTIDE;
D O I：
10.1016/j.talanta.2013.03.061
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
MicroRNAs (miRNAs) are a family of non-protein-coding, endogenous, small RNAs. They are a group of gene regulators that function mainly by binding the 3' untranslated regions of specific target messenger RNA (mRNA) leading to gene inactivation by repression of mRNA transcription or induction of mRNA. Mature miRNAs are short molecules approximately 22 nucleotides in length. They regulate a wide range of biological functions from cell proliferation and death to cancer progression. Cellular miRNA expression levels can be used as biomarkers for the onset of disease states and in gene therapy for genetic disorders. Methods for detection of miRNA mainly include northern blotting, microarray, polymerase chain reaction (PCR). This review focuses on the use of electrochemical biosensors for the detection of microRNA. (c) 2013 Elsevier B.V. All rights reserved.
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收藏
页码：74 / 83
页数：10
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