Natural Product Synthesis via the Rhodium Carbenoid-Mediated Cyclization of α-Diazo Carbonyl Compounds

被引：12
作者：
Padwa, Albert [1 ]
Cheng, Bo [1 ]
Zou, Yan [1 ]
机构：
[1] Emory Univ, Dept Chem, Atlanta, GA 30322 USA
来源：
AUSTRALIAN JOURNAL OF CHEMISTRY | 2014年 / 67卷 / 03期
基金：
美国国家科学基金会;
关键词：
INTRAMOLECULAR DIPOLAR CYCLOADDITIONS; DIELS-ALDER REACTION; CYCLIZATION/CYCLOADDITION CASCADE; ORGANIC-SYNTHESIS; CYCLO-ADDITIONS; TANDEM; MELODINUS; (+/-)-MELOSCINE; ALKALOIDS; CHEMISTRY;
D O I：
10.1071/CH13307
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The chemistry of metal carbene complexes has provided chemists with exceptionally fertile ground for designing and developing new stereoselective bond construction for application towards the synthesis of various natural products. In particular, the Rh-II-catalyzed reaction of 2-diazo-3-oxobutanoates bearing tethered pi-bonds represents a synthetically useful protocol for the construction of a variety of novel polycyclic skeletons. The related Rh-II-catalyzed reaction of the 2-diazo-2-(1H-indol-2-yl)acetate system has recently been examined as a potential route towards scandine, a member of the melodinus family of alkaloids.
引用
收藏
页码：343 / 353
页数：11
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