Biofunctionalized Prussian Blue Nanoparticles for Multimodal Molecular Imaging Applications
被引:15
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作者:
Vojtech, Jennifer M.
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机构:
Childrens Natl Med Ctr, Sheikh Zayed Inst Pediat Surg Innovat, Rockville, MD 20850 USA
Univ Maryland, Fischell Dept Bioengn, College Pk, MD USAChildrens Natl Med Ctr, Sheikh Zayed Inst Pediat Surg Innovat, Rockville, MD 20850 USA
Vojtech, Jennifer M.
[1
,2
]
Cano-Mejia, Juliana
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h-index: 0
机构:
Childrens Natl Med Ctr, Sheikh Zayed Inst Pediat Surg Innovat, Rockville, MD 20850 USA
Univ Maryland, Fischell Dept Bioengn, College Pk, MD USAChildrens Natl Med Ctr, Sheikh Zayed Inst Pediat Surg Innovat, Rockville, MD 20850 USA
Cano-Mejia, Juliana
[1
,2
]
Dumont, Matthieu F.
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机构:
Childrens Natl Med Ctr, Sheikh Zayed Inst Pediat Surg Innovat, Rockville, MD 20850 USAChildrens Natl Med Ctr, Sheikh Zayed Inst Pediat Surg Innovat, Rockville, MD 20850 USA
Dumont, Matthieu F.
[1
]
Sze, Raymond W.
论文数: 0引用数: 0
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机构:
Childrens Natl Med Ctr, Sheikh Zayed Inst Pediat Surg Innovat, Rockville, MD 20850 USA
George Washington Univ, Dept Radiol, Washington, DC 20052 USAChildrens Natl Med Ctr, Sheikh Zayed Inst Pediat Surg Innovat, Rockville, MD 20850 USA
Sze, Raymond W.
[1
,3
]
Fernandes, Rohan
论文数: 0引用数: 0
h-index: 0
机构:
Childrens Natl Med Ctr, Sheikh Zayed Inst Pediat Surg Innovat, Rockville, MD 20850 USA
George Washington Univ, Dept Radiol, Washington, DC 20052 USA
George Washington Univ, Dept Pediat, Washington, DC 20052 USAChildrens Natl Med Ctr, Sheikh Zayed Inst Pediat Surg Innovat, Rockville, MD 20850 USA
Fernandes, Rohan
[1
,3
,4
]
机构:
[1] Childrens Natl Med Ctr, Sheikh Zayed Inst Pediat Surg Innovat, Rockville, MD 20850 USA
[2] Univ Maryland, Fischell Dept Bioengn, College Pk, MD USA
[3] George Washington Univ, Dept Radiol, Washington, DC 20052 USA
[4] George Washington Univ, Dept Pediat, Washington, DC 20052 USA
来源:
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
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2015年
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98期
Multimodal, molecular imaging allows the visualization of biological processes at cellular, subcellular, and molecular-level resolutions using multiple, complementary imaging techniques. These imaging agents facilitate the real-time assessment of pathways and mechanisms in vivo, which enhance both diagnostic and therapeutic efficacy. This article presents the protocol for the synthesis of biofunctionalized Prussian blue nanoparticles (PB NPs) - a novel class of agents for use in multimodal, molecular imaging applications. The imaging modalities incorporated in the nanoparticles, fluorescence imaging and magnetic resonance imaging (MRI), have complementary features. The PB NPs possess a core-shell design where gadolinium and manganese ions incorporated within the interstitial spaces of the PB lattice generate MRI contrast, both in T-1 and T-2-weighted sequences. The PB NPs are coated with fluorescent avidin using electrostatic self-assembly, which enables fluorescence imaging. The avidin-coated nanoparticles are modified with biotinylated ligands that confer molecular targeting capabilities to the nanoparticles. The stability and toxicity of the nanoparticles are measured, as well as their MRI relaxivities. The multimodal, molecular imaging capabilities of these biofunctionalized PB NPs are then demonstrated by using them for fluorescence imaging and molecular MRI in vitro.
机构:
Univ Paris Sud Paris Saclay, Inst Chim Mol & Mat Orsay, UMR 8182, Bat 420, F-91405 Orsay, FranceUniv Paris Sud Paris Saclay, Inst Chim Mol & Mat Orsay, UMR 8182, Bat 420, F-91405 Orsay, France
机构:
Univ Autonoma Madrid, Dept Fis Mat, Nanomat Bioimaging Grp, C Francisco Tomas Y Valiente 7, Madrid 28049, SpainUniv Autonoma Madrid, Dept Fis Mat, Nanomat Bioimaging Grp, C Francisco Tomas Y Valiente 7, Madrid 28049, Spain
Munoz-Ortiz, Tamara
Hu, Jie
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机构:
Chinese Acad Sci, Xiamen Inst Rare Earth Mat, Haixi Inst, 258 Duishanxiheng Rd, Xiamen 361024, Fujian, Peoples R ChinaUniv Autonoma Madrid, Dept Fis Mat, Nanomat Bioimaging Grp, C Francisco Tomas Y Valiente 7, Madrid 28049, Spain
Hu, Jie
Ortgies, Dirk H.
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机构:
Univ Autonoma Madrid, Dept Fis Mat, Nanomat Bioimaging Grp, C Francisco Tomas Y Valiente 7, Madrid 28049, Spain
Hosp Ramon & Cajal, Inst Ramon Y Cajal Invest Sanitaria, Ctra Colmenar Km 9,100, Madrid 28034, SpainUniv Autonoma Madrid, Dept Fis Mat, Nanomat Bioimaging Grp, C Francisco Tomas Y Valiente 7, Madrid 28049, Spain
Ortgies, Dirk H.
Shrikhande, Shreya
论文数: 0引用数: 0
h-index: 0
机构:
Pompeu Fabra Univ, Dept Expt & Hlth Sci, Integrat Biomed Mat & Nanomed Lab, Carrer Doctor Aiguader 88, Barcelona 08003, SpainUniv Autonoma Madrid, Dept Fis Mat, Nanomat Bioimaging Grp, C Francisco Tomas Y Valiente 7, Madrid 28049, Spain
Shrikhande, Shreya
Zamora-Perez, Paula
论文数: 0引用数: 0
h-index: 0
机构:
Pompeu Fabra Univ, Dept Expt & Hlth Sci, Integrat Biomed Mat & Nanomed Lab, Carrer Doctor Aiguader 88, Barcelona 08003, SpainUniv Autonoma Madrid, Dept Fis Mat, Nanomat Bioimaging Grp, C Francisco Tomas Y Valiente 7, Madrid 28049, Spain
Zamora-Perez, Paula
Granado, Miriam
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机构:
Univ Autonoma Madrid, Fac Med, Dept Fisiol, Nanomat Bioimaging Grp, C Arzobispo Morcillo S-N, Madrid 28029, SpainUniv Autonoma Madrid, Dept Fis Mat, Nanomat Bioimaging Grp, C Francisco Tomas Y Valiente 7, Madrid 28049, Spain
Granado, Miriam
Gonzalez-Hedstrom, Daniel
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机构:
Univ Autonoma Madrid, Fac Med, Dept Fisiol, Nanomat Bioimaging Grp, C Arzobispo Morcillo S-N, Madrid 28029, SpainUniv Autonoma Madrid, Dept Fis Mat, Nanomat Bioimaging Grp, C Francisco Tomas Y Valiente 7, Madrid 28049, Spain
Gonzalez-Hedstrom, Daniel
de la Fuente-Fernandez, Maria
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机构:
Univ Autonoma Madrid, Fac Med, Dept Fisiol, Nanomat Bioimaging Grp, C Arzobispo Morcillo S-N, Madrid 28029, SpainUniv Autonoma Madrid, Dept Fis Mat, Nanomat Bioimaging Grp, C Francisco Tomas Y Valiente 7, Madrid 28049, Spain
de la Fuente-Fernandez, Maria
Luis Garcia-Villalon, Angel
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机构:
Univ Autonoma Madrid, Fac Med, Dept Fisiol, Nanomat Bioimaging Grp, C Arzobispo Morcillo S-N, Madrid 28029, SpainUniv Autonoma Madrid, Dept Fis Mat, Nanomat Bioimaging Grp, C Francisco Tomas Y Valiente 7, Madrid 28049, Spain
Luis Garcia-Villalon, Angel
Andres-Delgado, Laura
论文数: 0引用数: 0
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机构:
Univ Autonoma Madrid, Dept Anat Histol & Neurociencia, Fac Med, C Arzobispo Morcillo S-N, Madrid 28029, SpainUniv Autonoma Madrid, Dept Fis Mat, Nanomat Bioimaging Grp, C Francisco Tomas Y Valiente 7, Madrid 28049, Spain
Andres-Delgado, Laura
Martin Rodriguez, Emma
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机构:
Hosp Ramon & Cajal, Inst Ramon Y Cajal Invest Sanitaria, Ctra Colmenar Km 9,100, Madrid 28034, Spain
Univ Autonoma Madrid, Dept Fis Aplicada, Nanomat Bioimaging Grp, C Francisco Tomas Y Valiente 7, Madrid 28049, SpainUniv Autonoma Madrid, Dept Fis Mat, Nanomat Bioimaging Grp, C Francisco Tomas Y Valiente 7, Madrid 28049, Spain
Martin Rodriguez, Emma
Aguilar, Rio
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机构:
Univ Autonoma Madrid, Hosp Univ Princesa, Inst Invest Sanitaria Princesa IIS IP, Cardiol Dept,CIBER CV, Calle Diego de Leon 62, Madrid 28006, SpainUniv Autonoma Madrid, Dept Fis Mat, Nanomat Bioimaging Grp, C Francisco Tomas Y Valiente 7, Madrid 28049, Spain
Aguilar, Rio
Alfonso, Fernando
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机构:
Univ Autonoma Madrid, Hosp Univ Princesa, Inst Invest Sanitaria Princesa IIS IP, Cardiol Dept,CIBER CV, Calle Diego de Leon 62, Madrid 28006, SpainUniv Autonoma Madrid, Dept Fis Mat, Nanomat Bioimaging Grp, C Francisco Tomas Y Valiente 7, Madrid 28049, Spain
Alfonso, Fernando
Garcia Sole, Jose
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机构:
Univ Autonoma Madrid, Dept Fis Mat, Nanomat Bioimaging Grp, C Francisco Tomas Y Valiente 7, Madrid 28049, SpainUniv Autonoma Madrid, Dept Fis Mat, Nanomat Bioimaging Grp, C Francisco Tomas Y Valiente 7, Madrid 28049, Spain
Garcia Sole, Jose
Rivera Gil, Pilar
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机构:
Pompeu Fabra Univ, Dept Expt & Hlth Sci, Integrat Biomed Mat & Nanomed Lab, Carrer Doctor Aiguader 88, Barcelona 08003, SpainUniv Autonoma Madrid, Dept Fis Mat, Nanomat Bioimaging Grp, C Francisco Tomas Y Valiente 7, Madrid 28049, Spain
Rivera Gil, Pilar
Jaque, Daniel
论文数: 0引用数: 0
h-index: 0
机构:
Univ Autonoma Madrid, Dept Fis Mat, Nanomat Bioimaging Grp, C Francisco Tomas Y Valiente 7, Madrid 28049, Spain
Hosp Ramon & Cajal, Inst Ramon Y Cajal Invest Sanitaria, Ctra Colmenar Km 9,100, Madrid 28034, SpainUniv Autonoma Madrid, Dept Fis Mat, Nanomat Bioimaging Grp, C Francisco Tomas Y Valiente 7, Madrid 28049, Spain
Jaque, Daniel
Rivero, Fernando
论文数: 0引用数: 0
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机构:
Univ Autonoma Madrid, Hosp Univ Princesa, Inst Invest Sanitaria Princesa IIS IP, Cardiol Dept,CIBER CV, Calle Diego de Leon 62, Madrid 28006, SpainUniv Autonoma Madrid, Dept Fis Mat, Nanomat Bioimaging Grp, C Francisco Tomas Y Valiente 7, Madrid 28049, Spain