Bioconversion of 3-cyanopyridine to Nicotinic Acid by a Thermotable Nitrilase

被引：0
|
作者：
Nigam, V. K.
Agarwal, A.
Sharma, M.
Ghosh, P. [1 ]
Choudhury, B. [2 ]
机构：
[1] Birla Inst Sci Res, Jaipur 302001, Rajasthan, India
[2] Indian Inst Technol, Fac Biol Sci, Roorkee 247667, Uttaranchal, India
来源：
RESEARCH JOURNAL OF BIOTECHNOLOGY | 2009年 / 4卷 / 01期
关键词：
Nitrilase; 3-Cyanopyridine; Bacillus; Thermophilic; Biotransformation; RHODOCOCCUS-RHODOCHROUS J1; CATALYZED PRODUCTION; DEEP-SEA; PURIFICATION; ARYLACETONITRILASE; MANDELONITRILE; BIOCHEMISTRY; HYDROLYSIS; AMIDASE;
D O I：
暂无
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
A thermostable nitrilase producing isolate identified as Bacillus sp. MTCC 7545 has been studied towards production of nicotinic acid from 3-cyanopyridine. The benzonitrile was observed as inducer for the enzyme production. Maximum enzyme production was observed at 24 h of incubation and the activity of nitrilase was found to be optimum at 65 degrees C. The enzyme was stable for similar to 6 h at 50 degrees C. Besides pyridine-3 carbonitrile, benzonitrile was also a preferred substrate for the enzyme.
引用
收藏
页码：32 / 36
页数：5
相关论文
共 50 条
  • [41] 2-CYANOPYRIDINE, 3-CYANOPYRIDINE AND 4-CYANOPYRIDINE COMPLEXES WITH SOME ZINC(II), CADMIUM(II) AND MERCURY(II) SALTS
    AHUJA, IS
    SINGH, R
    JOURNAL OF INORGANIC & NUCLEAR CHEMISTRY, 1974, 36 (07): : 1505 - 1513
  • [42] An efficient synthesis of ferrocenyl substituted 3-cyanopyridine derivatives under ultrasound irradiation
    Zhou, WJ
    Ji, SJ
    Shen, ZL
    JOURNAL OF ORGANOMETALLIC CHEMISTRY, 2006, 691 (07) : 1356 - 1360
  • [43] Efficient Epoxidation of alkenes with aqueous hydrogen peroxide catalyzed by methyltrioxorhenium and 3-cyanopyridine
    Adolfsson, H
    Copéret, C
    Chiang, JP
    Yudin, AK
    JOURNAL OF ORGANIC CHEMISTRY, 2000, 65 (25): : 8651 - 8658
  • [44] In situ FTIR study of transformation of 3-cyanopyridine on V–Ti–O catalyst
    Yuriy A. Chesalov
    Galina Ya. Popova
    Galina B. Chernobay
    Tamara V. Andrushkevich
    Reaction Kinetics and Catalysis Letters, 2009, 98 : 43 - 50
  • [45] PROCESS CONDITIONS FOR OBTAINING HIGH YIELDS OF 3-CYANOPYRIDINE FROM 3-PICOLINE
    MATHEWS, S
    PRASAD, R
    INDIAN JOURNAL OF TECHNOLOGY, 1989, 27 (02): : 111 - 112
  • [46] In situ FTIR study of transformation of 3-cyanopyridine on V-Ti-O catalyst
    Chesalov, Yuriy A.
    Popova, Galina Ya.
    Chernobay, Galina B.
    Andrushkevich, Tamara V.
    REACTION KINETICS AND CATALYSIS LETTERS, 2009, 98 (01): : 43 - 50
  • [47] GAS-CHROMATOGRAPHIC DETERMINATION OF NICOTINAMIDE IN MEATS AND MEAT-PRODUCTS AS 3-CYANOPYRIDINE
    TANAKA, A
    IIJIMA, M
    KIKUCHI, Y
    HOSHINO, Y
    NOSE, N
    JOURNAL OF CHROMATOGRAPHY, 1989, 466 : 307 - 317
  • [48] One-pot synthesis and antimicrobial evaluation of novel 3-cyanopyridine derivatives of (-)-β-pinene
    Liao, Shengliang
    Shang, Shibin
    Shen, Minggui
    Rao, Xiaoping
    Si, Hongyan
    Song, Jie
    Song, Zhanqian
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2016, 26 (06) : 1512 - 1515
  • [49] Supercritical Water Oxidation of Pyridine and 3-Cyanopyridine: TOC Removal, Kinetics, and Degradation Pathway
    Yang, Bowen
    Shen, Zhemin
    JOURNAL OF ENVIRONMENTAL ENGINEERING, 2019, 145 (04)
  • [50] Application of continuous stirred membrane reactor to 3-cyanopyridine bioconversion using the nitrile hydratase-amidase cascade system of Microbacterium imperiale CBS 498-74
    Cantarella, L.
    Gallifuoco, A.
    Malandra, A.
    Martinkova, L.
    Pasquarelli, F.
    Spera, A.
    Cantarella, M.
    ENZYME AND MICROBIAL TECHNOLOGY, 2010, 47 (03) : 64 - 70
12345