Bioconversion of 3-cyanopyridine to Nicotinic Acid by a Thermotable Nitrilase

被引：0
|
作者：
Nigam, V. K.
Agarwal, A.
Sharma, M.
Ghosh, P. [1 ]
Choudhury, B. [2 ]
机构：
[1] Birla Inst Sci Res, Jaipur 302001, Rajasthan, India
[2] Indian Inst Technol, Fac Biol Sci, Roorkee 247667, Uttaranchal, India
来源：
RESEARCH JOURNAL OF BIOTECHNOLOGY | 2009年 / 4卷 / 01期
关键词：
Nitrilase; 3-Cyanopyridine; Bacillus; Thermophilic; Biotransformation; RHODOCOCCUS-RHODOCHROUS J1; CATALYZED PRODUCTION; DEEP-SEA; PURIFICATION; ARYLACETONITRILASE; MANDELONITRILE; BIOCHEMISTRY; HYDROLYSIS; AMIDASE;
D O I：
暂无
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
A thermostable nitrilase producing isolate identified as Bacillus sp. MTCC 7545 has been studied towards production of nicotinic acid from 3-cyanopyridine. The benzonitrile was observed as inducer for the enzyme production. Maximum enzyme production was observed at 24 h of incubation and the activity of nitrilase was found to be optimum at 65 degrees C. The enzyme was stable for similar to 6 h at 50 degrees C. Besides pyridine-3 carbonitrile, benzonitrile was also a preferred substrate for the enzyme.
引用
收藏
页码：32 / 36
页数：5
相关论文
共 50 条
  • [21] PRESSURE-FREE HYDROGENATION OF 3-CYANOPYRIDINE
    FISCHER, E
    REMBARZ, G
    FRANKE, P
    CHIMIA, 1969, 23 (04) : 155 - +
  • [22] 3-CYANOPYRIDINE AND 4-CYANOPYRIDINE COMPLEXES OF PENTACYANOFERRATE(II) AND PENTACYANOCOBALTATE(III)
    MORENO, NGDV
    KATZ, NE
    OLABE, JA
    AYMONINO, PJ
    INORGANICA CHIMICA ACTA, 1979, 35 (02) : 183 - 188
  • [23] Nicotinic acid bio-production by Microbacterium imperiale CBS 489-74. Effect of 3-cyanopyridine and temperature on amidase activity
    Cantarella, M.
    Cantarella, L.
    Gallifuoco, A.
    Spera, A.
    Martinkova, L.
    PROCESS BIOCHEMISTRY, 2012, 47 (07) : 1192 - 1196
  • [24] 3-Cyanopyridine as a bridging and terminal ligand in coordination polymers
    Heine, Miriam
    Fink, Lothar
    Schmidt, Martin U.
    CRYSTENGCOMM, 2018, 20 (46): : 7556 - 7566
  • [25] Crystal Engineering under Hydrothermal Conditions: Cocrystals and Reactions of 3-Cyanopyridine with Glutaric Acid
    Efe, Sevval
    Schauerte, Carsten
    Merz, Klaus
    CRYSTAL GROWTH & DESIGN, 2022, 22 (04) : 2272 - 2278
  • [26] Hydrolysis kinetics of 2-cyanopyridine, 3-cyanopyridine, and 4-cyanopyridine in high-temperature water
    Fu, Jie
    Ren, Haoming
    Shi, Chaojun
    Lu, Xiuyang
    INTERNATIONAL JOURNAL OF CHEMICAL KINETICS, 2012, 44 (09) : 641 - 648
  • [27] STUDIES ON THE REACTION OF 3-CYANOPYRIDINE WITH GRIGNARD-REAGENTS
    GAO, FL
    JIAO, KF
    DING, ZK
    SONG, HQ
    ACTA CHIMICA SINICA, 1987, 45 (09) : 922 - 925
  • [28] A copper(I) coordination polymer with 3-cyanopyridine ligands
    Deng, Cui-Er
    Zhu, Yu-Shu
    Zhang, Xue-Chun
    Tao, Yan-Lin
    Liu, Xi
    ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES, 2023, 78 (7-8): : 435 - 439
  • [29] Reproductive and developmental toxicity screening test of 3-cyanopyridine in rats
    Takahashi, Mika
    Yabe, Kaoru
    Kato, Hina
    Kawamura, Tomoko
    Matsumoto, Mariko
    Hirata-Koizumi, Mutsuko
    Ono, Atsushi
    Hirose, Akihiko
    REPRODUCTIVE TOXICOLOGY, 2013, 35 : 7 - 16
  • [30] Vertellus to Expand 3-Cyanopyridine and VB3 Production in China
    China Chemical Reporter, 2010, 21 (12) : 8 - 8
12345