missMethyl: an R package for analyzing data from Illumina's HumanMethylation450 platform

被引：513

作者：

Phipson, Belinda ^{[1
]}

Maksimovic, Jovana ^{[1
]}

Oshlack, Alicia ^{[1
]}

机构：

[1] Royal Childrens Hosp, Murdoch Childrens Res Inst, Bioinformat Grp, Parkville, Vic 3052, Australia

来源：

BIOINFORMATICS | 2016年 / 32卷 / 02期

基金：

英国医学研究理事会;

关键词：

METHYLATION; CANCER;

D O I：

10.1093/bioinformatics/btv560

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A Summary: DNA methylation is one of the most commonly studied epigenetic modifications due to its role in both disease and development. The Illumina HumanMethylation450 BeadChip is a cost-effective way to profile >450 000 CpGs across the human genome, making it a popular platform for profiling DNA methylation. Here we introduce missMethyl, an R package with a suite of tools for performing normalization, removal of unwanted variation in differential methylation analysis, differential variability testing and gene set analysis for the 450K array.

引用

页码：286 / 288

页数：3

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