Wnt3a promotes radioresistance via autophagy in squamous cell carcinoma of the head and neck

被引：41

作者：

Jing, Qiancheng ^{[1
,2
,3
]}

Li, Guo ^{[1
,2
]}

Chen, Xiyu ^{[1
,2
]}

Liu, Chao ^{[1
,2
]}

Lu, Shanhong ^{[1
,2
]}

Zheng, Hua ^{[1
,2
]}

Ma, Huiling ^{[1
,2
]}

Qin, Yuexiang ^{[1
,2
,4
]}

Zhang, Diekuo ^{[1
,2
]}

Zhang, Shuiting ^{[1
,2
]}

Ren, Shuling ^{[1
,2
]}

Huang, Donghai ^{[1
,2
]}

Tan, Pingqing ^{[5
]}

Chen, Jie ^{[5
]}

Qiu, Yuanzheng ^{[1
,2
]}

Liu, Yong ^{[1
,2
]}

机构：

[1] Cent S Univ, Xiangya Hosp, Dept Otolaryngol Head & Neck Surg, 87 Xiangya Rd, Changsha 410008, Hunan, Peoples R China

[2] Otolaryngol Major Dis Res Key Lab Hunan Prov, Changsha, Hunan, Peoples R China

[3] Univ South China, Changsha Cent Hosp, Dept Otolaryngol Head & Neck Surg, Changsha, Hunan, Peoples R China

[4] Cent S Univ, Xiangya Hosp 3, Hlth Management Ctr, Changsha, Hunan, Peoples R China

[5] Cent S Univ, Affiliated Tumor Hosp, Xiangya Med Sch, Hunan Canc Hosp,Dept Head & Neck Surg, Changsha, Hunan, Peoples R China

来源：

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE | 2019年 / 23卷 / 07期

基金：

中国国家自然科学基金;

关键词：

autophagy; prognosis; radioresistance; squamous cell carcinoma of the head and neck; Wnt3a; EPITHELIAL-MESENCHYMAL TRANSITION; NF-KAPPA-B; POOR-PROGNOSIS; BETA-CATENIN; EXPRESSION; CANCER; ASSOCIATION; PREDICTS; DISEASE; GROWTH;

D O I：

10.1111/jcmm.14394

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The canonical Wnt/beta-catenin signalling pathway and autophagy play critical roles in cancer progression. However, the role of Wnt-mediated autophagy in cancer radioresistance remains unclear. In this study, we found that irradiation activated the Wnt/beta-catenin and autophagic signalling pathways in squamous cell carcinoma of the head and neck (SCCHN). Wnt3a is a classical ligand that activated the Wnt/beta-catenin signalling pathway, induced autophagy and decreased the sensitivity of SCCHN to irradiation both in vitro and in vivo. Further mechanistic analysis revealed that Wnt3a promoted SCCHN radioresistance via protective autophagy. Finally, expression of the Wnt3a protein was elevated in both SCCHN tissues and patients' serum. Patients showing high expression of Wnt3a displayed a worse prognosis. Taken together, our study indicates that both the canonical Wnt and autophagic signalling pathways are valuable targets for sensitizing SCCHN to irradiation.

引用

页码：4711 / 4722

页数：12

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