Dysbiosis of gut microbiota and microbial metabolites in Parkinson's Disease

被引：323

作者：

Sun, Meng-Fei ^{[1
]}

Shen, Yan-Qin ^{[1
]}

机构：

[1] Jiangnan Univ, Wuxi Med Sch, Wuxi 214122, Jiangsu, Peoples R China

来源：

AGEING RESEARCH REVIEWS | 2018年 / 45卷

基金：

中国国家自然科学基金;

关键词：

Parkinson's disease; Gut microbiota; Short-chain fatty acids; Central nervous system; Microbial molecules; Microbiota-targeted therapies; CHAIN FATTY-ACIDS; INTESTINAL BACTERIAL OVERGROWTH; HELICOBACTER-PYLORI INFECTION; CENTRAL-NERVOUS-SYSTEM; BRAIN AXIS; CLOSTRIDIUM-DIFFICILE; INFLUENCES ANXIETY; HYDROGEN-SULFIDE; POTENTIAL ROLE; MURINE MODEL;

D O I：

10.1016/j.arr.2018.04.004

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Gut microbial dysbiosis and alteration of microbial metabolites in Parkinson's disease (PD) have been increasingly reported. Dysbiosis in the composition and abundance of gut microbiota can affect both the enteric nervous system and the central nervous system (CNS), indicating the existence of a microbiota-gut-brain axis and thereby causing CNS diseases. Disturbance of the microbiota-gut-brain axis has been linked to specific microbial products that are related to gut inflammation and neuroinflammation. Future directions should therefore focus on the exploration of specific gut microbes or microbial metabolites that contribute to the development of PD. Microbiota-targeted interventions, such as antibiotics, probiotics and fecal microbiota transplantation, have been shown to favorably affect host health. In this review, recent findings regarding alterations and the role of gut microbiota and microbial metabolites in PD are summarized, and potential molecular mechanisms and microbiota-targeted interventions in PD are discussed.

引用

页码：53 / 61

页数：9

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