Differentiation between non-Hodgkin's lymphoma recurrence and second primary lymphoma by VDJ rearrangement analysis

被引：15

作者：

Libra, M

De Re, V

Gasparotto, D

Gloghini, A

Marzotto, A

Milan, I

Tirelli, U

Stivala, F

Carbone, A

Boiocchi, M

机构：

[1] Ctr Riferimento Oncol, Div Expt Oncol 1, I-33081 Aviano, Italy

[2] Univ Catania, Dept Biomed Sci, Clin Pathol & Mol Oncol Sect, I-95124 Catania, Italy

[3] Ctr Riferimento Oncol, Div Pathol, I-33081 Aviano, Italy

[4] Ctr Riferimento Oncol, Div Med Oncol A, I-33081 Aviano, Italy

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2002年 / 118卷 / 03期

关键词：

non-Hodgkin's lymphoma; relapse; VDJ;

D O I：

10.1046/j.1365-2141.2002.03655.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Relapses in non-Hodgkin's lymphomas (NHL) could be due to the reappearance of the initial neoplasm or new primary tumours. Discrimination between the two events would allow a more targeted therapeutic approach. VDJ rearrangement was used as marker of clonality in metachronous biopsy specimens from 10 patients with relapsed B-NHL. Complimentarity determining region 3 was amplified and sequenced. D-JH was identical in eight matched primary/secondary tumours, confirming the diagnosis of recurrence. In contrast, primary and secondary tumours in two patients were of different clonal origin. Our data indicate that VDJ analysis is a fundamental tool for identificaton of relapses in NHL.

引用

页码：809 / 812

页数：4

共 13 条

[11] High-grade transformation of low-grade non-Hodgkin's lymphomas: Mechanisms of tumor progression [J].