Synthesis of β-Isoxazole Carbonyl Derivatives and Their Analogues via Palladium-Catalyzed Sequential C(sp2)-O/C(sp2)-C(sp3) Bond Formations

被引：15

作者：

Wu, Wanqing ^{[1
,2
]}

Li, Can ^{[2
]}

Zhou, Fei ^{[2
]}

Li, Jianxiao ^{[2
]}

Xu, Xiaoqing ^{[2
]}

Jiang, Huanfeng ^{[2
]}

机构：

[1] South China Univ Technol, State Key Lab Luminescent Mat & Devices, Guangzhou 510640, Guangdong, Peoples R China

[2] South China Univ Technol, Key Lab Funct Mol Engn Guangdong Prov, Sch Chem & Chem Engn, Guangzhou 510640, Guangdong, Peoples R China

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2019年 / 361卷 / 16期

基金：

中国国家自然科学基金;

关键词：

Palladium-catalyzed; beta-Aryl aldehydes; ketones; Allylic alcohols; Isoxazoles; TANDEM INTRAMOLECULAR AMINOPALLADATION; OXIDATIVE KINETIC RESOLUTION; ALLYLIC ALCOHOLS; HECK REACTION; MOLECULAR-OXYGEN; CONJUGATE ADDITION; ARYL KETONES; C-C; ALKYLATION; STRATEGY;

D O I：

10.1002/adsc.201900391

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

An efficient Pd(II)-catalyzed one-pot tandem cyclization/alkylation reaction of internal alkynes has been reported. In this reaction, a wide range of structurally diverse beta/beta-isoxazole aldehydes/ketones could be obtained in good to excellent yields from various alkynyl oxime ethers and allylic or homoallylic alcohols. The gram-scale experiment and various transformations of the newly obtained products demonstrated that this method should be a general and useful synthetic tool.

引用

页码：3813 / 3823

页数：11

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