Comparison of long-term follow-up outcomes between multiple-drugs combination therapy and tonsillectomy pulse therapy for pediatric IgA nephropathy

被引:6
作者
Kawasaki, Yukihiko [1 ]
Maeda, Ryo [1 ]
Kanno, Syuto [1 ]
Suzuki, Yuichi [1 ]
Ohara, Shinichiro [1 ]
Suyama, Kazuhide [1 ]
Hosoya, Mitsuaki [1 ]
机构
[1] Fukushima Med Univ, Dept Pediat, Sch Med, 1 Hikariga Oka, Fukushima, Fukushima 9601295, Japan
关键词
IgA nephropathy; Tonsillectomy plus methylprednisolone pulse therapy; Long-term follow-up; Outcome; Pediatrics; CLINICAL REMISSION; CONTROLLED-TRIAL; EFFICACY; METAANALYSIS;
D O I
10.1007/s10157-017-1515-5
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
To clarify the long-term efficacy of multiple-drugs combination therapy (PWDM) and tonsillectomy pulse therapy (TPT) for pediatric IgA nephropathy (IgAN), we retrospectively evaluated the clinical and laboratory findings as well as the prognosis for IgAN patients treated with each treatment at long-term follow-up. We collected data on 61 children who had been diagnosed with severe IgAN. The children were retrospectively divided into two groups. Group 1 consisted of 44 severe IgAN children treated with PWDM, and Group 2 consisted of 17 severe IgAN children treated with TPT. The clinical features, pathological findings, and prognosis were analyzed for both groups. The mean urinary protein excretion, serum creatinine, IgA levels, MESTCG scores, and percentage of glomeruli showing crescents in both groups at the second renal biopsy were lower than those at the first renal biopsy. At the time of the second biopsy, the IgA level in Group 2 was lower than that in Group 1; however, there were no significant differences in the mean urinary protein excretion, frequency of hematuria, serum albumin, creatinine, or e-GFR between the two groups. At the most recent follow-up, there were no significant differences in prognosis between the groups. Our study suggested that PWDM and TPT are effective in ameliorating urinary abnormalities and improving the long-term outcome of pediatric IgAN.
引用
收藏
页码:917 / 923
页数:7
相关论文
共 50 条
  • [21] Comparison of effective impact among tonsillectomy alone, tonsillectomy combined with oral steroid and with steroid pulse therapy on long-term outcome of immunoglobulin A nephropathy
    Yoshihiro Yamamoto
    Yoshiyuki Hiki
    Shigeru Nakai
    Koichiro Yamamoto
    Kazuo Takahashi
    Shigehisa Koide
    Kazutaka Murakami
    Makoto Tomita
    Midori Hasegawa
    Shiro Kawashima
    Satoshi Sugiyama
    Yukio Yuzawa
    Clinical and Experimental Nephrology, 2013, 17 : 218 - 224
  • [22] Proteinuria during Follow-Up Period and Long-Term Renal Survival of Childhood IgA Nephropathy
    Kamei, Koichi
    Harada, Ryoko
    Hamada, Riku
    Sakai, Tomoyuki
    Hamasaki, Yuko
    Hataya, Hiroshi
    Ito, Shuichi
    Ishikura, Kenji
    Honda, Masataka
    PLOS ONE, 2016, 11 (03):
  • [23] Lifetime progression of IgA nephropathy: a retrospective cohort study with extended long-term follow-up
    Rivedal, Mariell
    Nordbo, Ole Petter
    Haaskjold, Yngvar Lunde
    Bjorneklett, Rune
    Knoop, Thomas
    Eikrem, Oystein
    BMC NEPHROLOGY, 2025, 26 (01)
  • [24] Effectiveness of exercise therapy in craniomandibular disorders: a long-term follow-up
    Nicolakis, P
    Erdogmus, B
    Kopf, A
    Schmid-Schwap, M
    Ebenbichler, G
    Fialka-Moser, V
    PHYSIKALISCHE MEDIZIN REHABILITATIONSMEDIZIN KURORTMEDIZIN, 2001, 11 (02) : 51 - 55
  • [25] Long-term follow-up in depressed patients treated with electroconvulsive therapy
    Johanson, A
    Gustafson, L
    Risberg, J
    Rosén, I
    Sjöbeck, M
    Silfverskiöld, P
    JOURNAL OF ECT, 2005, 21 (04) : 214 - 220
  • [26] In utero exposure to antiretroviral therapy: feasibility of long-term follow-up
    Hankin, Claire
    Lyall, Hermione
    Willey, Barbara
    Peckham, Catherine
    Masters, Janet
    Tookey, Pat
    AIDS CARE-PSYCHOLOGICAL AND SOCIO-MEDICAL ASPECTS OF AIDS/HIV, 2009, 21 (07): : 809 - 816
  • [27] Long-Term Follow-Up of Pediatric Patients Treated with Mitoxantrone for Multiple Sclerosis
    Kornek, B.
    Bernert, G.
    Rostasy, K.
    Mlczoch, E.
    Feucht, M.
    Prayer, D.
    Vass, K.
    Seidl, R.
    NEUROPEDIATRICS, 2011, 42 (01) : 7 - 12
  • [28] Long-term follow-up after cognitive behaviour therapy for chronic fatigue syndrome
    Janse, Anthonie
    Nikolaus, Stephanie
    Wiborg, Jan F.
    Heins, Marianne
    van der Meer, Jos W. M.
    Bleijenberg, Gijs
    Tummers, Marcia
    Twisk, Jos
    Knoop, Hans
    JOURNAL OF PSYCHOSOMATIC RESEARCH, 2017, 97 : 45 - 51
  • [29] Long-term follow-up after proton beam therapy for pediatric tumors: a Japanese national survey
    Mizumoto, Masashi
    Murayama, Shigeyuki
    Akimoto, Tetsuo
    Demizu, Yusuke
    Fukushima, Takashi
    Ishida, Yuji
    Oshiro, Yoshiko
    Numajiri, Haruko
    Fuji, Hiroshi
    Okumura, Toshiyuki
    Shirato, Hiroki
    Sakurai, Hideyuki
    CANCER SCIENCE, 2017, 108 (03) : 444 - 447
  • [30] Therapy for Dupuytren's Disease: Collagenase Therapy-A Long-Term Follow-Up Study
    Wachtel, Nikolaus
    Dingler, Francesca Romana
    Nuernberger, Tim
    Vollbach, Felix Hubertus
    Moellhoff, Nicholas
    Giunta, Riccardo
    Demmer, Wolfram
    LIFE-BASEL, 2024, 14 (10):