Positron Emission Tomography imaging with the SmartPET system

被引:2
作者
Cooper, R. J. [1 ]
Boston, A. J. [1 ]
Boston, H. C. [1 ]
Cresswell, J. R. [1 ]
Grint, A. N. [1 ]
Harkness, L. J. [1 ]
Nolan, P. J. [1 ]
Oxley, D. C. [1 ]
Scraggs, D. P. [1 ]
Mather, A. R. [1 ]
Lazarus, I. [2 ]
Simpson, J. [2 ]
机构
[1] Univ Liverpool, Dept Phys, Liverpool L69 7ZE, Merseyside, England
[2] STFC, Daresbury Lab, Warrington WA4 4AD, Cheshire, England
基金
英国工程与自然科学研究理事会;
关键词
Planar HPGe detector; Pulse Shape Analysis; Positron Emission Tomography; SMALL ANIMAL PET; POSITION SENSITIVITY; HPGE;
D O I
10.1016/j.nima.2009.04.015
中图分类号
TH7 [仪器、仪表];
学科分类号
0804 ; 080401 ; 081102 ;
摘要
The Small Animal Reconstruction Tomograph for Positron Emission Tomography (SmartPET) project is the development of a small animal Positron Emission Tomography (PET) demonstrator based on the use of High-Purity Germanium (HPGe) detectors and state of the art digital electronics. The experimental results presented demonstrate the current performance of this unique system. By performing high precision measurements of one of the SmartPET HPGe detectors with a range of finely collimated gamma-ray beams the response of the detector as a function of gamma-ray interaction position has been quantified, facilitating the development of parametric Pulse Shape Analysis (PSA) techniques and algorithms for the correction of imperfections in detector performance. These algorithms have then been applied to data from PET imaging measurements using two such detectors in conjunction with a specially designed rotating gantry. In this paper we show how the use of parametric PSA approaches allows over 60% of coincident events to be processed and how the nature and complexity of an event has direct implications for the quality of the resulting image. (C) 2009 Elsevier B.V. All rights reserved.
引用
收藏
页码:523 / 532
页数:10
相关论文
共 31 条
  • [1] Three-dimensional position sensing and field shaping in orthogonal-strip germanium gamma-ray detectors
    Amman, M
    Luke, PN
    [J]. NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT, 2000, 452 (1-2) : 155 - 166
  • [2] Characterisation of the SmartPET planar germanium detectors
    Boston, H. C.
    Boston, A. J.
    Cooper, R. J.
    Cresswell, J.
    Grint, A. N.
    Mather, A. R.
    Nolan, P. J.
    Scraggs, D. P.
    Turk, G.
    Hall, C. J.
    Lazarus, I.
    Berry, A.
    Beveridge, T.
    Gillam, J.
    Lewis, R.
    [J]. NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT, 2007, 579 (01) : 104 - 107
  • [3] Chatziioannou Arion F, 2002, Mol Imaging Biol, V4, P47, DOI 10.1016/S1095-0397(01)00067-X
  • [4] CHERRY SR, 2001, PHYS NUCL MED
  • [5] Charge collection performance of a segmented planar high-purity germanium detector
    Cooper, R. J.
    Boston, A. J.
    Boston, H. C.
    Cresswell, J. R.
    Grint, A. N.
    Harkness, L. J.
    Nolan, P. J.
    Oxley, D. C.
    Scraggs, D. P.
    Lazarus, I.
    Simpson, J.
    Dobson, J.
    [J]. NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT, 2008, 595 (02) : 401 - 409
  • [6] SmartPET: Applying HPGe and pulse shape analysis to small-animal PET
    Cooper, R. J.
    Boston, A. J.
    Boston, H. C.
    Cresswell, J. R.
    Grint, A. N.
    Mather, A. R.
    Nolan, P. J.
    Scraggs, D. P.
    Turk, G.
    Hall, C. J.
    Lazarus, I.
    Berry, A.
    Beveridge, T.
    Gillam, J.
    Lewis, R. A.
    [J]. NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT, 2007, 579 (01) : 313 - 317
  • [8] DERENZO SE, 1998, IEEE T NUCL SCI, V35, P1
  • [9] DREZET A, 2004, IEEE NUCL SCI S
  • [10] GILLAM JE, 2008, IEEE MED IM C