Treatment of HIV infection with raltegravir

被引：0

作者：

Chirch, Lisa M. ^{[1
]}

Morrison, Sidonie A. ^{[1
]}

Steigbigel, Roy T. ^{[1
]}

机构：

[1] SUNY Stony Brook, Sch Med, Div Infect Dis, Stony Brook, NY 11794 USA

来源：

EXPERT OPINION ON PHARMACOTHERAPY | 2009年 / 10卷 / 07期

关键词：

antiretroviral therapy; HIV; human immunodeficiency virus; integrase inhibitor; raltegravir; INTEGRASE INHIBITOR RALTEGRAVIR; STRAND TRANSFER; PHARMACOKINETICS; TOLERABILITY; MK-0518; THERAPY; SAFETY; VIRUS;

D O I：

10.1517/14656560902911488

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Background: Raltegravir, an inhibitor of the HIV-1 integrase enzyme, is now available for the treatment of drug-resistant virus. Objective: To establish raltegravir as an effective addition to the existing antiretroviral armamentarium by reviewing pharmacokinetics, efficacy, safety and tolerability. Methods: Data from pharmacokinetic, Phase II and III clinical trials were reviewed. Results/conclusions: Results from clinical trials indicate that raltegravir is safe and highly effective in the treatment of both antiretroviral-naive and -experienced patients.

引用

页码：1203 / 1211

页数：9

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