Treatment of HIV infection with raltegravir

被引：0
作者：
Chirch, Lisa M. [1 ]
Morrison, Sidonie A. [1 ]
Steigbigel, Roy T. [1 ]
机构：
[1] SUNY Stony Brook, Sch Med, Div Infect Dis, Stony Brook, NY 11794 USA
来源：
EXPERT OPINION ON PHARMACOTHERAPY | 2009年 / 10卷 / 07期
关键词：
antiretroviral therapy; HIV; human immunodeficiency virus; integrase inhibitor; raltegravir; INTEGRASE INHIBITOR RALTEGRAVIR; STRAND TRANSFER; PHARMACOKINETICS; TOLERABILITY; MK-0518; THERAPY; SAFETY; VIRUS;
D O I：
10.1517/14656560902911488
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Background: Raltegravir, an inhibitor of the HIV-1 integrase enzyme, is now available for the treatment of drug-resistant virus. Objective: To establish raltegravir as an effective addition to the existing antiretroviral armamentarium by reviewing pharmacokinetics, efficacy, safety and tolerability. Methods: Data from pharmacokinetic, Phase II and III clinical trials were reviewed. Results/conclusions: Results from clinical trials indicate that raltegravir is safe and highly effective in the treatment of both antiretroviral-naive and -experienced patients.
引用
收藏
页码：1203 / 1211
页数：9
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