Prenatal activity from thalamic neurons governs the emergence of functional cortical maps in mice

被引:112
作者
Anton-Bolanos, Noelia [1 ]
Sempere-Ferrandez, Alejandro [1 ]
Guillamon-Vivancos, Teresa [1 ]
Martini, Francisco J. [1 ]
Perez-Saiz, Leticia [1 ]
Gezelius, Henrik [1 ]
Filipchuk, Anton [1 ,2 ]
Valdeolmillos, Miguel [1 ]
Lopez-Bendito, Guillermina [1 ]
机构
[1] UMH CSIC, Inst Neurociencias Alicante, Sant Joan dAlacant, Spain
[2] Univ Paris Sud, Dept Integrat & Computat Neurosci ICN, Paris Saclay Inst Neurosci NeuroPSI, CNRS, F-91198 Gif Sur Yvette, France
基金
瑞典研究理事会; 欧洲研究理事会;
关键词
CEREBRAL-CORTEX; CRITICAL PERIOD; NETWORK OSCILLATIONS; NEWBORN RAT; ORGANIZATION; ACTIVATION; BARRELS;
D O I
10.1126/science.aav7617
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The mammalian brain's somatosensory cortex is a topographic map of the body's sensory experience. In mice, cortical barrels reflect whisker input. We asked whether these cortical structures require sensory input to develop or are driven by intrinsic activity. Thalamocortical columns, connecting the thalamus to the cortex, emerge before sensory input and concur with calcium waves in the embryonic thalamus. We show that the columnar organization of the thalamocortical somatotopic map exists in the mouse embryo before sensory input, thus linking spontaneous embryonic thalamic activity to somatosensory map formation. Without thalamic calcium waves, cortical circuits become hyperexcitable, columnar and barrel organization does not emerge, and the somatosensory map lacks anatomical and functional structure. Thus, a self-organized protomap in the embryonic thalamus drives the functional assembly of murine thalamocortical sensory circuits.
引用
收藏
页码:987 / +
页数:46
相关论文
共 31 条
[31]   Thalamic Network Oscillations Synchronize Ontogenetic Columns in the Newborn Rat Barrel Cortex [J].
Yang, Jenq-Wei ;
An, Shuming ;
Sun, Jyh-Jang ;
Reyes-Puerta, Vicente ;
Kindler, Jennifer ;
Berger, Thomas ;
Kilb, Werner ;
Luhmann, Heiko J. .
CEREBRAL CORTEX, 2013, 23 (06) :1299-1316