A novel nutritional index "simplified CONUT" and the disease risk index independently stratify prognosis of elderly patients with acute myeloid leukemia

被引：12

作者：

Senjo, Hajime ^{[1
]}

Onozawa, Masahiro ^{[1
]}

Hidaka, Daisuke ^{[1
]}

Yokoyama, Shota ^{[1
]}

Yamamoto, Satoshi ^{[2
]}

Tsutsumi, Yutaka ^{[3
]}

Haseyama, Yoshihito ^{[4
]}

Nagashima, Takahiro ^{[5
]}

Mori, Akio ^{[6
]}

Ota, Shuichi ^{[7
]}

Sakai, Hajime ^{[8
]}

Ishihara, Toshimichi ^{[9
]}

Miyagishima, Takuto ^{[10
]}

Kakinoki, Yasutaka ^{[11
]}

Kurosawa, Mitsutoshi ^{[12
]}

Kobayashi, Hajime ^{[13
]}

Iwasaki, Hiroshi ^{[14
]}

Hashimoto, Daigo ^{[1
]}

Kondo, Takeshi ^{[6
]}

Teshima, Takanori ^{[1
]}

机构：

[1] Hokkaido Univ, Fac Med, Dept Hematol, Sapporo, Hokkaido, Japan

[2] Sapporo City Gen Hosp, Dept Hematol, Sapporo, Hokkaido, Japan

[3] Hakodate Municipal Hosp, Dept Hematol, Hakodate, Hokkaido, Japan

[4] Tonan Hosp, Dept Hematol, Sapporo, Hokkaido, Japan

[5] Japanese Red Cross Kitami Hosp, Dept Hematol, Kitami, Hokkaido, Japan

[6] Aiiku Hosp, Blood Disorders Ctr, Sapporo, Hokkaido, Japan

[7] Sapporo Hokuyu Hosp, Dept Hematol, Sapporo, Hokkaido, Japan

[8] Teine Keijinkai Hosp, Dept Hematol, Sapporo, Hokkaido, Japan

[9] Kin Ikyo Chuo Hosp, Dept Hematol, Sapporo, Hokkaido, Japan

[10] Kushiro Rosai Hosp, Dept Hematol, Kushiro, Hokkaido, Japan

[11] Asahikawa City Hosp, Dept Hematol, Asahikawa, Hokkaido, Japan

[12] Hokkaido Canc Ctr, Dept Hematol, Sapporo, Hokkaido, Japan

[13] Obihiro Kosei Gen Hosp, Dept Hematol, Obihiro, Hokkaido, Japan

[14] Sapporo Kosei Gen Hosp, Dept Hematol, Sapporo, Hokkaido, Japan

来源：

SCIENTIFIC REPORTS | 2020年 / 10卷 / 01期

关键词：

SCORE;

D O I：

10.1038/s41598-020-76250-8

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Elderly patients aged 65 or older with acute myeloid leukemia (AML) have poor prognosis. The risk stratification based on genetic alteration has been proposed in national comprehensive cancer network (NCCN) guideline but its efficacy was not well verified especially in real world elderly patients. The nutritional status assessment using controlling nutritional status (CONUT) score is a prognostic biomarker in elderly patients with solid tumors but was not examined in elderly AML patients. We performed prospective analysis of genetic alterations of 174 patients aged 65 or older with newly diagnosed AML treated without hematopoietic stem cell transplantation (HSCT) and developed simplified CONUT (sCONUT) score by eliminating total lymphocyte count from the items to adapt AML patients. In this cohort, both the NCCN 2017 risk group and sCONUT score successfully stratified the overall survival (OS) of the elderly patients. A multivariable analysis demonstrated that adverse group in NCCN 2017 and high sCONUT score were independently associated with poor 2-year OS. Both risk stratification based on NCCN 2017 and sCONUT score predict prognosis in the elderly patients with newly diagnosed AML.

引用

页数：7

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