From stem cells to red blood cells: how far away from the clinical application?

被引：8
作者：
Xie XiaoYan [1 ,2 ]
Li YanHua [1 ,2 ]
Pei XueTao [1 ,2 ]
机构：
[1] Beijing Inst Transfus Med, Stem Cell & Regenerat Med Lab, Beijing 100850, Peoples R China
[2] South China Res Ctr Stem Cell & Regenerat Med, Guangzhou 510005, Guangdong, Peoples R China
来源：
SCIENCE CHINA-LIFE SCIENCES | 2014年 / 57卷 / 06期
基金：
中国国家自然科学基金; 国家高技术研究发展计划(863计划);
关键词：
stem cells; red blood cells; differentiation; clinical application; HEMATOPOIETIC STEM; GENE CORRECTION; IPS CELLS; EX-VIVO; THALASSEMIA; GENERATION; PROGENITORS; EXPANSION; DIFFERENTIATION; ERYTHROBLASTS;
D O I：
10.1007/s11427-014-4667-5
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The generation of red blood cells (RBCs) from stem cells provides a solution for deficiencies in blood transfusion. Currently, primary hematopoietic stem cells, embryonic stem cells and induced pluripotent stem cells have shown the potential to produce fully mature RBCs. Here, we discuss the advantages, induction protocols, progress and possible clinical applications of stem cells in RBC production.
引用
收藏
页码：581 / 585
页数：5
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