The application of a thiohydroxamic acid (THA) linker in the solid-phase synthesis of a urea library

被引：5

作者：

Whitehead, DM

Jackson, T

McKeown, SC

Routledge, A ^{[1
]}

机构：

[1] Univ York, Dept Chem, York YO1 5DD, N Yorkshire, England

[2] GlaxoSmithKline Res & Dev Ltd, Med Res Ctr, Stevenage SG1 2NY, Herts, England

来源：

REACTIVE & FUNCTIONAL POLYMERS | 2002年 / 52卷 / 02期

基金：

英国工程与自然科学研究理事会;

关键词：

urea; solid-support; thiohydroxamic acid; recycle;

D O I：

10.1016/S1381-5148(02)00082-2

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A library of mona- and bis-ureas were synthesised on resin derivatised with a thiohydroxamic acid (THA) linker. The ureas were obtained in good yields and the resin was recycled three times with no apparent loss of function. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：81 / 87

页数：7

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