COVID-19 and Skin Manifestations: An Overview of Case Reports/Case Series and Meta-Analysis of Prevalence Studies

被引：23

作者：

Sameni, Fatemeh ^{[1
]}

Hajikhani, Bahareh ^{[2
]}

Yaslianifard, Somayeh ^{[3
]}

Goudarzi, Mehdi ^{[2
]}

Owlia, Parviz ^{[4
]}

Nasiri, Mohammad Javad ^{[2
]}

Shokouhi, Shervin ^{[5
,6
]}

Bakhtiyari, Mahmood ^{[7
,8
]}

Dadashi, Masoud ^{[3
,7
]}

机构：

[1] Shahed Univ, Dept Microbiol, Fac Med, Tehran, Iran

[2] Shahid Beheshti Univ Med Sci, Sch Med, Dept Microbiol, Tehran, Iran

[3] Alborz Univ Med Sci, Sch Med, Dept Microbiol, Karaj, Iran

[4] Shahed Univ, Mol Microbiol Res Ctr, Tehran, Iran

[5] Shahid Beheshti Univ Med Sci, Infect Dis & Trop Med Res Ctr, Tehran, Iran

[6] Shahid Beheshti Univ Med Sci, Loghman Hakim Hosp, Dept Infect Dis & Trop Med, Tehran, Iran

[7] Alborz Univ Med Sci, Noncommunicable Dis Res Ctr, Karaj, Iran

[8] Alborz Univ Med Sci, Dept Community Med, Karaj, Iran

来源：

FRONTIERS IN MEDICINE | 2020年 / 7卷

关键词：

coronavirus; 2019-nCoV; COVID-19; skin manifestations; meta-analysis; CORONAVIRUS DISEASE 2019; CLINICAL CHARACTERISTICS;

D O I：

10.3389/fmed.2020.573188

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background and Aim: Since the onset of the 2019-nCoV disease (COVID-19), many skin manifestations have been reported in COVID-19 patients. This study aims to provide a systematic review and meta-analysis of various skin manifestations among patients with COVID-19 through case reports/case series and prevalence studies. Methods: A systematic literature search strategy was conducted by reviewing original research articles published in Medline, Web of Science, and Embase databases in 2020. Statistical analysis was performed using STATA software, version 14.0 (Stata Corporation, College Station, Texas, USA) to report the global prevalence of skin manifestations among patients with COVID-19. Results: Forty-three studies (35 articles were case reports/case series, and 8 articles were prevalence studies) were included in our study. A meta-analysis of prevalence studies showed that skin manifestations among patients with COVID-19 were reported in four countries (China, Thailand, France, and Italy), with an overall prevalence of 1.0% [(95% CI) 0.1-1.9] among 2,621 patients. Evaluation of the results of the case reports/case series revealed that, out of 54 patients with COVID-19, 48 patients (88.8%) showed skin manifestations. Erythematous rash (59.1%) and urticaria (14.8%) were the most common skin manifestation reported in studied patients. Conclusion: Infection with 2019-nCoV may lead to skin manifestations with various clinical symptoms. These clinical features combined with clinical symptoms of COVID-19 may aid in the timely diagnosis of patients with COVID-19.

引用

页数：14