Attenuation of quorum sensing-mediated virulence of Acinetobacter baumannii by Glycyrrhiza glabra flavonoids

被引：42
|
作者：
Bhargava, Nidhi [1 ]
Singh, Sukhvinder P. [2 ]
Sharma, Anupam [3 ]
Sharma, Prince [4 ]
Capalash, Neena [1 ]
机构：
[1] Panjab Univ, Dept Biotechnol, Chandigarh 160014, India
[2] Cent Coast Primary Ind Ctr, NSW Dept Primary Ind, Gosford, NSW 2250, Australia
[3] Panjab Univ, Univ Inst Pharmaceut Sci, Chandigarh 160014, India
[4] Panjab Univ, Dept Microbiol, Chandigarh 160014, India
来源：
FUTURE MICROBIOLOGY | 2015年 / 10卷 / 12期
关键词：
Acinetobacter baumannii; biofilm; catalase; flavonoids; Glycyrrhiza glabra; motility; quorum sensing inhibition; superoxide dismutase; PSEUDOMONAS-AERUGINOSA; BIOFILM FORMATION; SIGNAL MOLECULES; INHIBITION; EXPRESSION; MOTILITY; GENES; PLANT; TARGET;
D O I：
10.2217/fmb.15.107
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Aim: To develop an alternative quorum quenching therapy against multidrug-resistant Acinetobacter baumannii. Methods & results: Activity-guided partially purified fraction (F1) from Glycyrrhiza glabra significantly (p < 0.05) reduced quorum sensing regulated virulence factors of A. baumannii viz. motility, biofilm formation and production of antioxidant enzymes. Mechanistically, F1 downregulated the expression of autoinducer synthase gene, abaI, and consequently reduced (92%) the production of 3-OH-C12-HSL as determined by ESI-MS. Q-TOF and Q-TRAP analyses suggested the presence of flavonoids viz. licoricone, glycyrin and glyzarin as the active ingredients. Conclusion: This is the first report on quorum quenching activity of G. glabra linked to its flavonoids that downregulated the expression of abaI and attenuated quorum sensing regulated virulence of A. baumannii.
引用
收藏
页码：1953 / 1968
页数：16
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