Attenuation of quorum sensing-mediated virulence of Acinetobacter baumannii by Glycyrrhiza glabra flavonoids

被引：42
|
作者：
Bhargava, Nidhi [1 ]
Singh, Sukhvinder P. [2 ]
Sharma, Anupam [3 ]
Sharma, Prince [4 ]
Capalash, Neena [1 ]
机构：
[1] Panjab Univ, Dept Biotechnol, Chandigarh 160014, India
[2] Cent Coast Primary Ind Ctr, NSW Dept Primary Ind, Gosford, NSW 2250, Australia
[3] Panjab Univ, Univ Inst Pharmaceut Sci, Chandigarh 160014, India
[4] Panjab Univ, Dept Microbiol, Chandigarh 160014, India
来源：
FUTURE MICROBIOLOGY | 2015年 / 10卷 / 12期
关键词：
Acinetobacter baumannii; biofilm; catalase; flavonoids; Glycyrrhiza glabra; motility; quorum sensing inhibition; superoxide dismutase; PSEUDOMONAS-AERUGINOSA; BIOFILM FORMATION; SIGNAL MOLECULES; INHIBITION; EXPRESSION; MOTILITY; GENES; PLANT; TARGET;
D O I：
10.2217/fmb.15.107
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Aim: To develop an alternative quorum quenching therapy against multidrug-resistant Acinetobacter baumannii. Methods & results: Activity-guided partially purified fraction (F1) from Glycyrrhiza glabra significantly (p < 0.05) reduced quorum sensing regulated virulence factors of A. baumannii viz. motility, biofilm formation and production of antioxidant enzymes. Mechanistically, F1 downregulated the expression of autoinducer synthase gene, abaI, and consequently reduced (92%) the production of 3-OH-C12-HSL as determined by ESI-MS. Q-TOF and Q-TRAP analyses suggested the presence of flavonoids viz. licoricone, glycyrin and glyzarin as the active ingredients. Conclusion: This is the first report on quorum quenching activity of G. glabra linked to its flavonoids that downregulated the expression of abaI and attenuated quorum sensing regulated virulence of A. baumannii.
引用
收藏
页码：1953 / 1968
页数：16
相关论文
共 50 条
  • [21] Reducing Quorum Sensing-Mediated Virulence Factor Expression and Biofilm Formation in Hafnia alvei by Using the Potential Quorum Sensing Inhibitor L-Carvone
    Li, Tingting
    Mei, Yongchao
    He, Binbin
    Sun, Xiaojia
    Li, Jianrong
    FRONTIERS IN MICROBIOLOGY, 2019, 9
  • [22] Inhibitive Effect of Eugenol and Its Nanoemulsion on Quorum Sensing-Mediated Virulence Factors and Biofilm Formation by Pseudomonas aeruginosa
    Lou, Zaixiang
    Letsididi, Kekgabile S.
    Yu, Fuhao
    Pei, Zejun
    Wang, Hongxin
    Letsididi, Rebaone
    JOURNAL OF FOOD PROTECTION, 2019, 82 (03) : 379 - 389
  • [23] The role of quorum sensing, biofilm formation, and iron acquisition as key virulence mechanisms in Acinetobacter baumannii and the corresponding anti-virulence strategies
    Law, Soffi Kei Kei
    Tan, Hock Siew
    Microbiological Research, 2022, 260
  • [24] The role of quorum sensing, biofilm formation, and iron acquisition as key virulence mechanisms in Acinetobacter baumannii and the corresponding anti-virulence strategies
    Law, Soffi Kei Kei
    Tan, Hock Siew
    MICROBIOLOGICAL RESEARCH, 2022, 260
  • [25] ω-Hydroxyemodin Limits Staphylococcus aureus Quorum Sensing-Mediated Pathogenesis and Inflammation
    Daly, Seth M.
    Elmore, Bradley O.
    Kavanaugh, Jeffrey S.
    Triplett, Kathleen D.
    Figueroa, Mario
    Raja, Huzefa A.
    El-Elimat, Tamam
    Crosby, Heidi A.
    Femling, Jon K.
    Cech, Nadja B.
    Horswill, Alexander R.
    Oberlies, Nicholas H.
    Hall, Pamela R.
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2015, 59 (04) : 2223 - 2235
  • [26] Attenuation of Pseudomonas aeruginosa virulence by quorum sensing inhibitors
    Hentzer, M
    Wu, H
    Andersen, JB
    Riedel, K
    Rasmussen, TB
    Bagge, N
    Kumar, N
    Schembri, MA
    Song, ZJ
    Kristoffersen, P
    Manefield, M
    Costerton, JW
    Molin, S
    Eberl, L
    Steinberg, P
    Kjelleberg, S
    Hoiby, N
    Givskov, M
    EMBO JOURNAL, 2003, 22 (15): : 3803 - 3815
  • [27] Regulatory and innovative mechanisms of bacterial quorum sensing-mediated pathogenicity: a review
    Tripathi, Sonam
    Purchase, Diane
    Govarthanan, Muthusamy
    Chandra, Ram
    Yadav, Sangeeta
    ENVIRONMENTAL MONITORING AND ASSESSMENT, 2023, 195 (01)
  • [28] Quorum sensing molecules production by nosocomial and soil isolates Acinetobacter baumannii
    Erdonmez, Demet
    Rad, Abbas Yousefi
    Aksoz, Nilufer
    ARCHIVES OF MICROBIOLOGY, 2017, 199 (10) : 1325 - 1334
  • [29] Quorum sensing molecules production by nosocomial and soil isolates Acinetobacter baumannii
    Demet Erdönmez
    Abbas Yousefi Rad
    Nilüfer Aksöz
    Archives of Microbiology, 2017, 199 : 1325 - 1334
  • [30] The abaI/abaR Quorum Sensing System Effects on Pathogenicity in Acinetobacter baumannii
    Sun, Xiaoyu
    Ni, Zhaohui
    Tang, Jie
    Ding, Yue
    Wang, Xinlei
    Li, Fan
    FRONTIERS IN MICROBIOLOGY, 2021, 12
12345